Advanced MRI in Major Depression

Completed

• Conditions: Depressive Disorder, Major
• Interventions: Other: Magnetic Resonance Imaging

• Registration Number: NCT00613912
• Lead Sponsor: University of Aarhus

Brief Summary

Depression is the most common psychiatric disorder.

* 3-5% of a given population has major depression.

* Less than 50% of the depressed in Denmark are diagnosed with major depression.

* 25-50% of the depressed have a relative with major depression-underlying brain pathology?

The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Detailed Description

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed.

MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.

Study Timeline

• Study First Submitted: 2008-01-31
• Study First Submitted QC: 2008-01-31
• Study First Posted: 2008-02-13
• Study Start: 2008-03
• Primary Completion: 2009-12
• Study Completion: 2011-06
• Status Verified: 2011-11
• Last Update Submitted: 2011-11-18
• Last Update Posted: 2011-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

• Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18

Exclusion Criteria

• If the patient has pacemaker or other magnetic devices
• Pregnancy
• Has had an operation in the brain
• bipolar disorder

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A	Magnetic Resonance Imaging	Ambulant patients with major depression

Primary Outcome Measures

Name	Time	Method
Differences in morphological and functional cerebral MRI findings in patients suffering from major depression	6 months from first MRI in each patient

Trial Locations

Locations (1)

Aalborg Hospital / Aarhus University Hospital; 🇩🇰 Aalborg, Jutland, Denmark