A Phase IB Study FOLFIRINOX and NIS793 in Patients With Pancreatic Cancer
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 发起方
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Safety Run In-Recommended Phase 2 dose (RP2D)
研究概览
简要总结
This research is being done to evaluate the safety and effectiveness of the drug NIS793 in combination with the standard of care treatment FOLFIRINOX (consists of the drugs 5-Fluorouracil (5-FU), Oxaliplatin, Irinotecan, and Leucovorin), chemoradiation and surgery for people with metastatic pancreas adenocarcinoma.
The drugs involved in this study are:
- NIS793
- FOLFIRINOX (consists of the drugs 5-Fluorouracil (5-FU), Oxaliplatin, Irinotecan, and Leucovorin)
Other interventions include
- chemoradiation
- surgery.
详细描述
This is a two part Phase 1B study investigating whether NIS793 improves the clinical benefit of FOLFIRINOX treatment for metastatic pancreas adenocarcinoma.The first part is a safety run-in using a dose escalation strategy to determine the recommended phase 2 dose of the drug NIS793. In the second part participants will be a randomized assigned to receive either FOLFIRINOX plus NIS793 or FOLFIRINOX alone.
NIS793 binds to the protein that can be found on tumor cells, called TGFβ, thereby preventing its role in cancer metastasis (spreading). FOLFIRINOX is a combination of 4 chemotherapy drugs that may help shrink tumors.
The U.S. Food and Drug Administration (FDA) has not approved NIS793 as a treatment for any disease.
The FDA has approved FOLFIRINOX as a treatment option for metastatic pancreas adenocarcinoma The FDA has not approved the combination of NIS793 and FOLFIRINOX as a treatment for any disease.
The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Safety Run-in Cohort: Histologically confirmed metastatic pancreatic adenocarcinoma without prior therapy for pancreatic adenocarcinoma.
- •Phase 1B Cohort: Histologically confirmed locally advanced disease (borderline resectable or locally advanced pancreatic adenocarcinoma) or poorly differentiated adenosquamous carcinoma includes both borderline resectable or locally advanced disease. Patients with localized pancreas adenocarcinoma cannot have received any prior therapy for borderline resectable or locally advanced pancreas adenocarcinoma
- •Borderline Resectable Disease: Defined by the NCCN as tumors with venous involvement of the SMV/portal vein demonstrated tumor abutment with or without impingement and narrowing of the lumen, either tumor thrombus or encasement but with suitable vessel proximal and distal to the area of vessel involvement, allowing for safe resection or reconstruction; gastroduodenal artery encasement up to the hepatic artery with either short segment encasement or direct abutment of the hepatic artery, without extension to the celiac axis; or tumor abutment of the SMA not to exceed greater than 180 degrees of the circumference of the vessel wall.Tumors involving retroperitoneal structures that can be surgically removed (i.e.kidney), will also be included.
- •Locally Advanced Pancreas Adenocarcinoma: Defined by the NCCN as: Tumors of the head that have greater than 180 degrees of SMA encasement or any celiac abutment, unreconstructable SMV or portal occlusion, or aortic invasion or encasement. Tumors of the body with SMA or celiac encasement of greater than 180 degrees, unreconstructable SMV or portal occlusion, or aortic invasion. Tumors of the tail with SMA or celiac encasement of greater than 180 degrees. Irrespective of location, all tumors with evidence of nodal metastasis outside of the resection field are deemed unresectable. Participants must have measurable disease, defined as at least one lesion that measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as ≥20 mm (≥2 cm) by chest x-ray or as ≥10 mm (≥1 cm) with CT scan, MRI, or calipers by clinical exam. See Section 12 (Measurement of Effect) for the evaluation of measurable disease.
- •Age ≥18 years.
- •ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A).
- •Participants must have adequate organ and marrow function as defined below:
- •Absolute neutrophil count ≥1,500/mcL
- •Platelets ≥100,000/mcL
- •Total bilirubin ≤ 1.5 institutional upper limit of normal (ULN) if no biliary stenting has been done OR 2.0 x ULN if patient is status post biliary stenting or two downward trending values.
- •AST(SGOT)/ALT(SGPT) Safety Run-in Metastatic Disease: < 5 x institutional ULN. Locally advanced disease: ≤3 × institutional ULN
- •Creatinine ≤ institutional ULN OR
- •Glomerular filtration rate (GFR) no lower than 60 mL/min/1.73 m2
- •Creatinine clearance for males = (140 - age [yrs]) (body wt [kg]) / (72) (serum creatinine [mg/dL])
- •Creatinine clearance for females = 0.85 x male value
- •Human immunodeficiency virus (HIV)-infected participants on effective antiretroviral therapy with undetectable viral load within 6 months are eligible for this trial.
- •For participants with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
- •Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. For participants with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.
- •Participants with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression. Additionally, participants with new or progressive brain metastases (active brain metastases) or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required and is unlikely to be required during the first cycle of therapy.
- •Participants with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
- •Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.
- •To be eligible for this trial, participants should be class. To be eligible for study participation, participants must be class 2 B or better.
- •The effects of treatment on the developing human fetus are unknown. For this reason, all patients of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation and 9 months after completion of mFOLFIRINOX or NIS793 administration. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
- •Ability to understand and the willingness to sign a written informed consent document.
排除标准
- •Metastatic Disease Safety Run-in: Any prior chemotherapy, radiation therapy, immunotherapy, biologic ('targeted') therapy or investigational therapy for pancreas adenocarcinoma.
- •Locally Advanced Disease Cohort: Any prior chemotherapy, radiation therapy, immunotherapy, biologic ('targeted') therapy or investigational therapy for treatment of the patient's pancreatic tumor.
- •Major surgery, excluding laparoscopy, within 4 weeks of the start of study treatment, without complete recovery
- •Patients with deficient mismatch/microsatellite unstable or high tumor mutation burden cancers.
- •Participation in any investigational drug study within 4 weeks preceding the start of study treatment.
- •Participants who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities > Grade 1) with the exception of alopecia.
- •Patients requiring use of steroids to treat active uncontrolled brain metastases will be excluded from study enrollment. Patients treated with radiation > 4 weeks prior with follow up imaging showing control are eligible.
- •History of allergic reactions attributed to compounds of similar chemical or biologic composition to NIS793, 5-fluorouracil, irinotecan and oxaliplatin not amenable to institutional chemotherapy desensitization protocol.
- •Known, existing uncontrolled coagulopathy. Concomitant treatment with full dose warfarin (coumadin) is NOT allowed. Patients may receive low molecular weight heparin (LMWH) (such as enoxaparin and dalteparin) and direct oral anticoagulant (DOAC) for management of deep venous thrombosis (DVT).
- •History of bleeding diathesis or recent major bleeding events (i.e. Grade > 2 bleeding events in the month prior to treatment).
- •Concomitant use of cimetidine, as it can decrease clearance of 5FU. Another H2- blocker or proton pump inhibitor may be substituted before study entry.
- •Patient with cardiac ventricular arrhythmias requiring antiarrhythmic therapy, or atrioventricular heart block (due to 5FU administration)
- •Participants with uncontrolled intercurrent illness or infection.
- •Participants with uncontrolled seizures, central nervous system disorders or psychiatric illness/social situations that would limit compliance with study requirements.
- •Has received a live vaccine within 30 days of planned start of study therapy. Note:
- •Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowed. COVID non-live vaccines are allowed.
- •History of severe hypersensitivity reaction to any monoclonal antibody.
- •Patient with known history of UGT1A1 gene polymorphism, Patient with known history of UGT1A1 gene polymorphism.
研究组 & 干预措施
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: Leucovorin (Drug)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: Irinotecan (Drug)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: 5-Fluorouracil (5-FU) (Drug)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: Chemoradiation (Radiation)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: Capecitabine (Drug)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: Radiation Therapy (Radiation)
Safety Run-In
Following a 3 + 3 dose escalation design 6-18 participants will receive NIS793 and FOLFIRINOX on day 1 of each 14 day cycle for 3+ cycles until recommended phase 2 dose is determined.
干预措施: FOLFIRINOX (Drug)
Safety Run-In
Following a 3 + 3 dose escalation design 6-18 participants will receive NIS793 and FOLFIRINOX on day 1 of each 14 day cycle for 3+ cycles until recommended phase 2 dose is determined.
干预措施: NIS793 (Drug)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: FOLFIRINOX (Drug)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: Oxaliplatin (Drug)
FOLFIRINOX
Participants will be randomly assigned to receive:
- FOLFIRINOX on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) and surgery
干预措施: Surgery (Procedure)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: FOLFIRINOX (Drug)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: Oxaliplatin (Drug)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: Leucovorin (Drug)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: Irinotecan (Drug)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: 5-Fluorouracil (5-FU) (Drug)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: NIS793 (Drug)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: Chemoradiation (Radiation)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: Capecitabine (Drug)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: Radiation Therapy (Radiation)
FOLFIRINOX + NIS793
Participants will be randomly assigned to receive:
- FOLFIRINOX FOLFIRINOX + NIS793 on day 1 of each 14 day cycle for cycles 1-8
- Cycles 9+: Chemoradiation (CRT) with NIS793, Surgery, NIS793
干预措施: Surgery (Procedure)
结局指标
主要结局
Safety Run In-Recommended Phase 2 dose (RP2D)
时间窗: Up to 2 months after baseline
Primary endpoint of safety run-in cohort is to define the recommended phase 2 dose as analyzed by 2-dimensional imaging (Computed Tomography, CT) or MRI utilizing Response Evaluation Criteria in Solid Tumors (RECIST v.1.1), obtained at 4-cycle therapy intervals.
R0 Resection Rate
时间窗: Up to 8 months after baseline
The primary endpoint of the two-arm non-comparative phase IB study (Part 2) is to estimate the R0 resection rate associated with the FOLFIRINOX/NIS793 therapy administered as neoadjuvant therapy.
次要结局
- Disease-Free Survival (DFS)(Up to approximately 6 years after baseline)
- Progression-free survival (PFS)(Up to approximately 6 years after baseline)
- Overall survival (OS)(Up to approximately 6 years after baseline)
- Pathologic complete response (pCR)(up to 8 months after baseline)
- Resection rate(up to 8 months after baseline)
研究者
Colin D. Weekes, M.D., PhD
Principal Investigator
Massachusetts General Hospital