Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
- Conditions
- Alzheimer Disease, Early Onset
- Interventions
- Other: Placebo
- Registration Number
- NCT06268886
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 310
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - BMS-986446 Dose B BMS-986446 - BMS-986446 Dose A BMS-986446 -
- Primary Outcome Measures
Name Time Method Change from baseline in brain tau deposition as measured by tau positron emission tomography (PET) At week 76
- Secondary Outcome Measures
Name Time Method Change from baseline in Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score At week 76 Change from baseline in integrated Alzheimer's Disease Rating Scale (iADRS) score At week 76 Change from baseline in Alzheimer's Disease Assessment Scale-Cognitive subscale (ADASCog14) score At week 76 Change from baseline in Alzheimer's Disease Cooperative Study-instrumental Activities of Daily Living scale (ADCS-iADL) score At week 76 Change from baseline in Mini Mental State Examination (MMSE) score At week 76
Related Research Topics
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Trial Locations
- Locations (176)
Local Institution - 0068
🇺🇸Chandler, Arizona, United States
Local Institution - 0102
🇺🇸Gilbert, Arizona, United States
Local Institution - 0019
🇺🇸Phoenix, Arizona, United States
Local Institution - 0018
🇺🇸Scottsdale, Arizona, United States
Local Institution - 0026
🇺🇸Scottsdale, Arizona, United States
Local Institution - 0077
🇺🇸Tucson, Arizona, United States
Local Institution - 0038
🇺🇸Tucson, Arizona, United States
Local Institution - 0164
🇺🇸Encino, California, United States
Local Institution - 0139
🇺🇸Fullerton, California, United States
Local Institution - 0191
🇺🇸Irvine, California, United States
Scroll for more (166 remaining)Local Institution - 0068🇺🇸Chandler, Arizona, United States