Study on Communication Comprehension in the Schizophrenic Spectrum

Not Applicable

Completed

• Conditions: Schizophrenia Simple
• Interventions: Behavioral: Emotional judgment task; Behavioral: Post-experimental questionnaire; Behavioral: Recognition task; Behavioral: Detection task; Other: CAPE-42; Diagnostic Test: Trait Emotional Intelligence Questionnaire; Diagnostic Test: Positive And Negative Syndrome Scale; Other: Mini International Neuropsychiatric Interview

• Registration Number: NCT03225027
• Lead Sponsor: Hôpital NOVO

Brief Summary

The purpose of the present study is to evaluate the effect of emotional prosody on the perception of emotional discourse in the schizophrenic spectrum. The investigators hypothesize that participant may use emotional prosody as an emotional cue to understand the emotional content of discourse.

Detailed Description

The integration of ortholinguistic and paralinguistic functions in language, particularly of the emotional prosody, is necessary to interact adaptively with others. People in the schizophrenic spectrum have social difficulties. Is emotional prosody comprehension altered in these people? According to Edwards et al. (2002), there is methodological issues concerning the tasks used to answer this question. Investigators built an emotional judgment task more adapted to study the perception of emotional prosody in the schizophrenic spectrum than the classical paradigm designed to evaluate participants with cerebral injury. The investigators have elaborated a material that consists of 140 short sentences (7±2 words) with a simple syntactic structure. The verbal content expressed positive, neutral or negative emotions. These sentences were announced by four professional actors (two female) with an emotional prosody content congruent or inconsistent with the verbal content. Participants will have to evaluate the emotional intensity of the recordings on a five points Likert scale, from strongly negative to strongly positive. Psychotic experiences of all participants will be evaluated too.

Study Timeline

• Study Start: 2016-11-15
• Study First Submitted: 2017-07-17
• Study First Submitted QC: 2017-07-19
• Study First Posted: 2017-07-21
• Primary Completion: 2019-05-27
• Study Completion: 2019-05-27
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-26
• Last Update Posted: 2019-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• Having a diagnosis of schizophrenia and being in a stable phase of the disease
• Having between 18 to 60 years old
• Speak french or using french at school
• Accepting not to use psychoactive substances during the preceding 48h
• Being affiliated to the French social security
• Providing their written informed consent

Non-inclusion Criteria:

• Having not audio deficits, nor visual uncorrected deficits
• Having not suffering from depressive symptoms during the last 6 months

Exclusion Criteria

• Having no neurological, nor psychiatric disease except schizophrenia for the patients groups.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Few psychotic experiences	Detection task	Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Several psychotic experiences	Detection task	Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Several psychotic experiences	CAPE-42	Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Patients with schizophrenia	Detection task	Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.
Patients with schizophrenia	Emotional judgment task	Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.
Patients with schizophrenia	Post-experimental questionnaire	Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.
Patients with schizophrenia	Recognition task	Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.
Few psychotic experiences	Recognition task	Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Few psychotic experiences	CAPE-42	Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Several psychotic experiences	Recognition task	Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Patients with schizophrenia	CAPE-42	Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.
Patients with schizophrenia	Positive And Negative Syndrome Scale	Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.
Few psychotic experiences	Post-experimental questionnaire	Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Patients with schizophrenia	Trait Emotional Intelligence Questionnaire	Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.
Few psychotic experiences	Emotional judgment task	Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Few psychotic experiences	Trait Emotional Intelligence Questionnaire	Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Few psychotic experiences	Mini International Neuropsychiatric Interview	Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Several psychotic experiences	Emotional judgment task	Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Several psychotic experiences	Post-experimental questionnaire	Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Several psychotic experiences	Trait Emotional Intelligence Questionnaire	Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview
Several psychotic experiences	Mini International Neuropsychiatric Interview	Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview

Primary Outcome Measures

Name	Time	Method
Behavioural measures (response rate and time)	During the experiment	Participants will have to judge the emotional intensity of audio recordings. In this task, the participant is asked to judge the emotional intensity of audio recordings of men and women (2 actors + 2 actresses): he / she must press a button as quickly as possible to indicate whether the Audio recordings presented via small speakers are very negative, negative, non-emotional, positive or very positive (5 possible choices).; The response time variable may be added as a co-variable in order to avoid perceptive-motor disorders (medication-related and / or general motor slowdown) that may influence the results of time-of- answers.

Secondary Outcome Measures

Name	Time	Method
Symptomatic impact	During the experiment	Evaluate the nature of the psychotic experiments (CAPE-42 test).
Evaluate the cognitive functioning	During the experiment	Neuropsychological tests will allow evaluating the cognitive profile of the participants that can impact their behaviour during the experiment.

Trial Locations

Locations (1)

HDJ François Villon; 🇫🇷 Cergy-Pontoise, France