A randomized double blind placebo-controlled trial: comparison of azithromycin with doxycycline prophylaxis against leptospirosis in human in an endemic area

Vice Chancellor for Research, Mazandaran University of Medical Sciences0 个研究点目标入组 270 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

暂无简介。

•Inclusion criteria
•All persons residing in endemic area of this disease and will supposed to work in the paddy field after taking a verified consent; All persons in the range of 18- 65 years old; Negative screening test for leptospirosis ; Agree to apply the doxycycline / azithromycin / placebo for all the times of paddy work ; Willing to regular monitoring for clinical manifestation; Willing to regular monitoring for three intermittent screening testing; Agree to report daily water contact; Agree to consult the related physician prior to taking any medication; No history of allergies to azithromycin or related compounds; No history of allergies to doxycycline or related compounds
•Exclusion criteria:All persons who have positive first screening test for leptospirosis ;When the persons have hypersensitivity to azithromycin and doxycycline in history ; Pregnant women for doxycycline group; Severe adverse reaction for example; severe photosensitivity due to doxycycline;Severe adverse reaction to azithromycin;All persons who don’t agree to enroll in the research;All persons who don’t agree consent form

发起方

Vice Chancellor for Research, Mazandaran University of Medical Sciences