Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration

Recruiting

• Conditions: Atherosclerosis
• Interventions: Other: Optical Coherence Tomography (OCT) and Computed Tomography Angiography (CTA)

• Registration Number: NCT04523194
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

The purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (OCT), computed tomography angiograms (CTA) and cardiac magnetic resonance imaging (CMR) for future studies. The main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.

Detailed Description

The purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (OCT), computed tomography angiograms (CTA) and cardiac magnetic resonance imaging (CMR) for future studies. About one thousand patients who underwent coronary angiography with OCT and had a CTA prior to catheterization at Tsuchiura Kyodo General Hospital (TKGH) in Japan, will be included. A subset of these patients also had CMR. The main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.

Study Timeline

• Study First Submitted: 2020-08-14
• Study First Submitted QC: 2020-08-20
• Study First Posted: 2020-08-21
• Study Start: 2020-11-09
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-25
• Last Update Posted: 2024-11-26
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Had CTA prior to cardiac catheterization and then OCT during catheterization

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Acute Coronary Syndrome	Optical Coherence Tomography (OCT) and Computed Tomography Angiography (CTA)	Patients diagnosed with acute coronary syndrome.
Stable Angina	Optical Coherence Tomography (OCT) and Computed Tomography Angiography (CTA)	Patients diagnosed with stable angina.

Primary Outcome Measures

Name	Time	Method
Major Adverse Cardiac Events (MACE)	1 Year	MACE

Trial Locations

Locations (2)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States

Tsuchiura Kyodo General Hospital; 🇯🇵 Tsuchiura, Japan