Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy
- Registration Number
- NCT05818007
- Lead Sponsor
- Yuzuncu Yıl University
- Brief Summary
Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients. The aim of this study was to investigate the effect of hyaluronic acid (HA) gel on OM in children receiving CT.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- children who receive chemotherapy
- hospitalized patient
Exclusion Criteria
- Allergy about using drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sodium bicarbonate Sodium bicarbonate - hyaluronic acid Hyaluronic acid The hyaluronic acid is a natural polysaccharide composed of D-glucuronic acid and N-acetyl-D-glucosamine and is synthesized as a linear polymer. The majority of the cells have a capacity to synthesize HA at a varying extent in the cell cycle.
- Primary Outcome Measures
Name Time Method VAS pain score Day 11th A Visual Analogue Scale (VAS) is one of the pain rating scales between 1-10.
World Health Organization Common Toxicity Criteria Scale day 11th The lesions were classified as Grade 0 = absent; Grade 1 = pain and erythema; Grade 2 = erythema and ulcers with no difficulty in swallowing solid food; Grade 3 = ulcers requiring only liquid diet; and Grade 4 = requiring parenteral and enteral nutrition support.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Yuzuncu Yil University
🇹🇷Van, Turkey
Yuzuncu Yil University🇹🇷Van, Turkey