The Effects of Nanocurcumin on Serum Oxidative Stress,Inflammation,Adiponectin and NF-kB in Blood Mononuclear Cells in Metabolic Syndrome Patients (Nuclear Factor-κB)
- Conditions
- Metabolic Syndrome
- Interventions
- Dietary Supplement: nanomicielle curcuminDietary Supplement: placebo
- Registration Number
- NCT03514667
- Lead Sponsor
- National Nutrition and Food Technology Institute
- Brief Summary
Metabolic syndrome is a public health challenge that includes a range of conditions including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. The syndrome is associated with an increase in the risk of Cardiovascular disease and death. Curcumin is a very active compound obtained from turmeric root. Curcumin has antioxidant and anti-inflammatory effects, and is also involved in the regulation of several signaling pathways. Since curcumin powder has low bioavailability, fast metabolism and low absorption, nanomicielle curcumin will be used in this study. Therefore, this study is planned to determine the effects of supplementation of nanomicielle curcumin on oxidative stress, systemic inflammation, adiponectin in serum and NF-kB in peripheral blood mononuclear cells in patients with metabolic syndrome.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- 25<body mass index >40
- waist circumference >102 cm in men or >88 cm in women
- Fasting blood glucose >100 mg/dL
- Triglycerides (TG) > 150 mg/dL
- High density lipoprotein cholesterol (HDL-C) <50 in women or <40 in men
- Systolic blood pressure (SBP) >130 mmHg and diastolic blood pressure (DBP) >85mmHg
- insulin administration for diabetes control
- hypo- or hyperthyroidism,
- renal failure or other chronic diseases
- pregnancy and breastfeeding
- taking weight loss supplements and obeying unusual weight loss plans
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description intervention group nanomicielle curcumin 80 mg nanomicielle curcumin capsules once a day for 12 weeks control group placebo placebo capsules once a day for 12 weeks
- Primary Outcome Measures
Name Time Method Serum C-reactive protein (CRP) 12weeks Serum Adiponectin 12weeks Serum Total antioxidant capacity (TAC) 12 weeks Serum Malondialdehyde (MDA) 12weeks Serum curcumin 12 weeks NF-kB(p65) transcription in PBMC 12weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Golbon Sohrab
🇮🇷Tehran, National Nutrition And Food Technology Research Institute, Iran, Islamic Republic of