Evaluation of Dietary Approach for Reduced Inflammation and Enhanced Recovery (DARIER) as a nutritional strategy to modulate inflammatory markers, immune function and fatigue in athletes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- i. Inflammatory Markers: Assessment of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels.
研究概览
简要总结
Introduction:
Endurance athletes experience complex physiological responses like inflammation, and immune function alterations during training. Dietary choices, particularly those with a high Dietary Inflammatory Index (DII), can impact these responses. A low DII diet potentially benefits athletes by reducing inflammation, supporting immunity, and enhancing recovery.
Methods:
This randomized controlled trial will investigate the effects of the DARIER diet (low DII) on athletes (n=80) over 12 weeks. Participants will be randomized to either the intervention group receiving the DARIER diet or the control group maintaining their usual diet. Primary outcomes include changes in inflammatory markers, and immune function. Secondary outcomes include performance measures and self-reported fatigue levels.
Discussion:
This study will contribute to understanding the impact of the DARIER diet on athlete health and performance. If effective, the DARIER approach could provide evidence-based dietary recommendations for athletes, improving their health, recovery, and performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 28.00 Year(s)（—）
- 性别
- All
入选标准
- •Endurance athletes aged 18-28 years, long distance runners, participants of state and University level will be recruited in the study.
- •ii.Engaged in regular endurance training for the past 3 or more years.
- •No history of chronic diseases or metabolic disorders.
排除标准
- •i.Presence of any chronic medical conditions affecting dietary intake, metabolism, or exercise performance.
- •Use of medications or supplements known to affect inflammatory markers, immune function.
结局指标
主要结局
i. Inflammatory Markers: Assessment of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels.
时间窗: At baseline and at 3 months
ii. Immune Function: Evaluation of immune cell counts (lymphocytes and neutrophils) interleukin-4 (IL-4).
时间窗: At baseline and at 3 months
次要结局
- i. Performance Measures: Endurance performance tests (VO2 max test).(ii. Subjective Measures: Self-reported fatigue levels)
研究者
Divya Sanghi
Manav Rachna International Institute of Research and Studies