Evaluation of clinical, neurophysiological and imaging parameter to detect and characterize chronic central neuropathic pain after spinal cord injury

• Conditions: G82.4; M79.2; Spastic tetraplegia; Neuralgia and neuritis, unspecified

• Registration Number: DRKS00006779
• Lead Sponsor: Klinik für Paraplegiologie,Universitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09-23
• Study Completion: 2021-10-01
• Results First Posted: 2023-05-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

Able to consent; chronic spinal cord injury at least 12 months post injury; neurological Level of injury C5 to Th10

Exclusion Criteria

Sensory impairment in dermatome C2 on both sides; artificial respiration; cauda-equina syndrome; epilepsy; impaired cognitive ablilities; pre-existing mental disorder; cardiac pacemaker; other active implants (e.g. phrenic pacemaker, drug pumps); metal implants less than 20 cm away from electrodes for electrical stimulation; severe traumatic brain injury in clinical history; pre-existing sensory deficits or dieseases which entail polyneuropathy (e.g. diabetes mellitus); severe primary internistic diseases (e.g. oncological, cardilogical); pregnancy.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Detection of neuropathic pain in chronic spinal cord injured patients by means of pain questionnaires and subsequent evaluation of findings from (1) Quantitative Sensory Testing/clinical examination, (2) H-Reflex/flexor-reflex/LEP/SSEP and (3) magnetic resonance imaging (VBM) compared to findings from the same methods in chronic spinal cord injured patients without neuropathic pain and healthy subjects.

Secondary Outcome Measures

Name	Time	Method
Influenceability of these parameters by sensorimotor activation.