Speech treatment in Autosomal recessive spastic ataxia of Charlevoix-Saguenay

Not Applicable

Completed

• Conditions: Autosomal recessive spastic ataxia of Charlevoix-Saguenay; Dysarthria; Ataxia; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders; Neurological - Neurodegenerative diseases; Physical Medicine / Rehabilitation - Speech therapy

• Registration Number: ACTRN12616001583437
• Lead Sponsor: The University of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-11-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Diagnosis of Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

Exclusion Criteria

No diagnosis of Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intelligibility as examined by blinded raters using direct magnitude estimation [Baseline and at 4 weeks (and 8 weeks for group B) post baseline. Then at 4 weeks post completion of treatment for both groups ];Naturalness as examined by blinded raters using direct magnitude estimation[Baseline and at 4 weeks (and 8 weeks for group B) post baseline. Then at 4 weeks post completion of treatment for both groups ]

Secondary Outcome Measures

Name	Time	Method
Speech-related quality of life using the Dysarthria Impact Profile [Baseline and immediately post completion of treatment for both groups];Overall disease severity using the Scale for the assessment and rating of ataxia (SARA) [Baseline and at 4 weeks (and 8 weeks for group B) post baseline. Then at 4 weeks post completion of treatment for both groups ];Acoustic analysis of speech: mean pause length[Baseline and at 4 weeks (and 8 weeks for group B) post baseline. Then at 4 weeks post completion of treatment for both groups ];Acoustic analysis of voice: harmonics to noise ratio using praat[Baseline and at 4 weeks (and 8 weeks for group B) post baseline. Then at 4 weeks post completion of treatment for both groups ];Acoustic analysis of speech: speech rate calculated by dividing syllables per second[Baseline and at 4 weeks (and 8 weeks for group B) post baseline. Then at 4 weeks post completion of treatment for both groups]