Evaluate a Medication on How Hunger and Appetite Are Influenced by Smell
- Registration Number
- NCT01021176
- Lead Sponsor
- Pennington Biomedical Research Center
- Brief Summary
The purpose of this study is to determine whether the blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray which will then reduce food intake.
- Detailed Description
You will fast on your first visit. Complete questionnaire about taste and smell to insure you don't have a cold or anything that would interfere with sense of smell. Your nose will be checked. Blood pressure taken, and administer to you a spray with diltiazem 2, 4, 8 mg or a placebo. Your sense of smell will be tested at different time points.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- Body mass index (BMI) between 25 and 40 kg
- Blood pressure in within normal range
Exclusion Criteria
- Used tobacco products in the past month
- Used a calcium channel blocker medication in the last month
- used nasal sprays in the last month
- have an abnormal sense of smell or abnormalities of the lining in your nose
- female and have irregular menstrual periods
- female and are nursing a baby or pregnant
- female and have had a partial hysterectomy (still have ovaries)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 4mg 4 Spray Diltiazem Staff member will administer an atomizer (device that changes a liquid into a fine spray) that will go into both nostrils. The atomizer will contain diltiazem, RxC Use 4mg/4 spray Diltiazem 8mg 8 spray Diltiazem Staff member will administer an atomizer (device that changes a liquid into a fine spray) that will go into both nostrils. The atomizer will contain diltiazem, RxC Use 8mg/8 spray Diltiazem 0mg 0 spray Placebo spray No Diltiazem 2mg 2 Spray Diltiazem Staff member will administer an atomizer (device that changes a liquid into a fine spray) that will go into both nostrils. The atomizer will contain diltiazem, RxC Use 2mg/2 spray Diltiazem
- Primary Outcome Measures
Name Time Method Evidence of blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray. 3 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Pennington Biomedical Research Center
🇺🇸Baton Rouge, Louisiana, United States