Prospective, interventional study on the characterization of circulatoryTumor cells and nucleic acids in patients undergoing aLung carcinoma surgery or pulmonary metastasisctomy(Pilot study)
- Conditions
- C34Malignant neoplasm of bronchus and lung
- Registration Number
- DRKS00007565
- Lead Sponsor
- niversitätsklinikum Freiburg - Klinik für Thoraxchirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 29
Group A:
- submission of written consent from the patient after informing
- Age = 18 years
Diagnosis of primary lung carcinoma or pulmonary metastases
- indication for surgical resection (atyp. Resection, lobectomy,
Pneumonectomy, metastasisctomy)
- In patients who are operated on a malignancy, the
Histopathological findings including the adequate examinations
be. No additional biopsy, examination or intervention must be within the framework
Of the study.
Group B:
-template the written consent of the patient after informing
- Age = 18 years
- Patients who have neither a history nor a suspected malignancy
(Other than basal cell carcinoma) and a lung operation due to a benign
Cause a basic disease.
Group A:
pregnancy
- Diagnosis of a second (synchronous) malignoma, except basal cell carcinoma.
- hemoglobin <8 g / dl on the morning of operation
- Intraoperative transfusion of more than four erythrocyte concentrates
Group B:
pregnancy
- Diagnosis of malignancy other than basal cell carcinoma.
- hemoglobin <8 g / dl on the morning of operation
- Intraoperative transfusion of more than four erythrocyte concentrates. No more
Blood collection will be taken during or on the first postoperative day.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Creation of a molecular profile of the present tumor disease using the<br>Analysis of CTCs and circulating nucleic acids in the local tumor compartment and systemically in primary and secondary lung tumors
- Secondary Outcome Measures
Name Time Method - Tumor recidiv<br>- Overall survival<br> - Genetic consistency of the CTCs in the local tumor compartment and systemic<br> - Comparison of different methods and removal points for the isolation of CTCs<br> -comparison cDNA, miRNA and clncRNA in the surgical preparation with the circulating RNAs systemically as well as from the immediate tumor discharge<br>- Expression of driver mutations of the CTCs