A COMPARATIVE STUDY ON EFFECTIVENESS OF SUGAMMADEX AND NEOSTIGMINE IN REVERSING VECURONIUM AND CISTARACURIUM INDUCED NEUROMUSCULAR BLOCK
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- 1.To study the efficacy of sugammadex in the reversal of vecuronium induced neuromuscular block among patients receiving general anesthesia
研究概览
简要总结
This study is an observational study comparing the effectiveness of Sugammadex versus Neostigmine in reversing neuromuscular block induced by Vecuronium and Cisatracurium, respectively, in adult patients undergoing elective surgeries under general anaesthesia. The primary objective is to assess the time taken to achieve a TOF ratio more than or equal to 0.9 using acceleromyography, along with evaluation of immediate postoperative recovery.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.American Society of Anesthesiologists (ASA) I / II.
- •2.Elective surgery under general anesthesia 3.Mallampatti Grades of I and II.
排除标准
- •1.Patients with a history of drug allergy to any of the studied drugs 2.Patients with difficulty in communication and pregnancy 3.Patients with significant neurologic, psychiatric, hepatic, renal or cardiac disease.
- •4.Morbid obesity (BMI more than 40) 5.a history of recent respiratory tract infection or sore throat anticipated difficult airway.
结局指标
主要结局
1.To study the efficacy of sugammadex in the reversal of vecuronium induced neuromuscular block among patients receiving general anesthesia
时间窗: TOF ratio at 0,1,2,3,4,5 minutes
2.To study the efficacy of neostigmine in the reversal of cisatracurium induced neuromuscular block among patients receiving general anesthesia
时间窗: TOF ratio at 0,1,2,3,4,5 minutes
3.To compare the efficacy of sugammadex in the reversal of vecuronium induced neuromuscular block and neostigmine in reversal of cisatracurium induced neuromuscular block among patients receiving general anesthesia
时间窗: TOF ratio at 0,1,2,3,4,5 minutes
次要结局
未报告次要终点
研究者
PAUL VARGHESE
Amala Institute of Medical Sciences