The Cardiac Autonomic Nervous System State and Response to Reflective, Motor and Cognitive Stimuli Among Patients Post Stroke: A Follow-up Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Tel-Aviv Sourasky Medical Center
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- RMSSD change
- Last Updated
- 13 years ago
Overview
Brief Summary
The study describes the autonomic control system function in subjects post stroke in comparison with healthy subjects.
Aims: To describe the Autonomic hart rate control system function in post stroke subjects in different rehabilitation levels in comparison with healthy subjects.
To examine the reflective reaction of the autonomic control system as reflected in the heart rate variability to stimulations subjects in different rehabilitation levels in comparison with healthy subjects.
To examine the autonomic control system reaction as reflected in the heart rate variability to physical and cognitive action subjects in different rehabilitation levels in comparison with healthy subjects.
Detailed Description
Subjects will be examined 3 times: a week 1 and 3 month post stroke. Control consist similar in description healthy subjects, will be examined once. Each test includes 24 hours Holter surveillance and an examine that include general check that reflects the autonomic reaction to different manipulation. The examination description: A. Prior to the examination subjects will be asked to fill the mRS, NIHSS forms. B. Subjects will receive an examination that includes * General neurological examination (strength, deep and superficial sensation, cognitive test and pain level.) C. Holter will be place for 24 hours. And autonomic examination test will be conducted * Grip Test: emphases the sympathetic system. * Breathing Test: emphases the parasympathetic system. D. Manipulation to examine the two sub systems. Each manipulation lasts1 minute.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Post hemispheral ischemic stroke cognitively intact.
Exclusion Criteria
- •Subjects with severe visual or hearing impairments, stroke location brain steam.
Outcomes
Primary Outcomes
RMSSD change
Time Frame: 3 month post stroke
The root mean square successive difference (RMSSD) in heart period series is a time domain measure of heart period variability. we will follow up the change in RMSSD at 1st and 3rd month post stroke
Secondary Outcomes
- 6mwt(3 month post stroke)
- Patient's characteristics(3 month post stroke)