Corticospinal Excitability and Rehab in Knee Osteoarthritis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Knee Osteoarthritis
- Sponsor
- Creighton University
- Enrollment
- 61
- Locations
- 1
- Primary Endpoint
- Change in quadriceps force output and voluntary activation
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
To determine differences in thigh muscle function in individuals with and without knee arthritis, and also determine the effectiveness of common physical therapy interventions on clinical and patient oriented outcomes.
Detailed Description
The primary objective of the proposed research evaluates the concurrent changes in corticospinal excitability and central sensitization of pain pathways for their influence on quadriceps voluntary activation. A secondary objective is to establish the feasibility of an intervention study to determine if changes in the excitability of these supraspinal motor and sensory processes can be modified by physical therapy interventions targeting pain and muscle strengthening. We hypothesize that patients with knee osteoarthritis will show measurable deficits in quadriceps voluntary activation that can be explained by lower levels of corticospinal excitability and increased pain sensitization. A 1 week physical therapy intervention will improve voluntary activation and reduce pain with concurrent changes in underlying motor and sensory processes. We further hypothesize that part of this improvement will be attributed to positive treatment expectation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 19-65
- •Grade I or II knee Osteoarthritis confirmed by radiographs or other imaging and at least one of the following:
- •Age \> 50 years old
- •Morning stiffness \< 30 minutes
- •Meet at least 3 of 6 diagnostic criteria for osteoarthritis:
- •Age \> 50 years old
- •Morning stiffness \< 30 minutes
- •Bony tenderness
- •Bony enlargement
- •No palpable warmth
Exclusion Criteria
- •BMI \> 30
- •History of traumatic spine or lower extremity injury within the last 6 months
- •Previous adverse reaction to electrical stimulation (i.e. burns or hypersensitivity)
- •Cardiac pacemaker
- •Metal implants in head
- •Current pregnancy
- •Neurological disorders
- •History of seizures
- •Unable to give consent or understand the procedures of this study
Outcomes
Primary Outcomes
Change in quadriceps force output and voluntary activation
Time Frame: Baseline and following 1 week intervention (2 Study Visits)
Quadriceps activation will be estimated by utilizing the burst-superimposition technique on a maximum voluntary isometric contraction (MVIC) and during a resting condition. The burst-superimposition technique provides the muscle with a percutaneous stimulus to recruit any remaining muscle fibers which have not been stimulated.