ISRCTN56552248已完成不适用
Prospective Randomized Trial of the Effects of Rosuvastatin on the Progression of Stenosis in Adult Patients with Congenital Aortic Stenosis
Erasmus Medical Center, Department of Cardiology (Netherlands)0 个研究点目标入组 180 人开始时间: 2006年1月27日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 180
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Valvular congenital aortic stenosis with a maximum aortic jet velocity >2.5 m/s
- •2. Age 18-45 years
排除标准
- •1. Use of statins or other study medication
- •2. Subvalvular or supravalvular aortic stenosis
- •3. Aortic regurgitation >2+
- •4. Malignancy within last 2 years
- •5. Aortic valve replacement in past
- •6. Rheumatic fever in past
- •7. Significant concomitant mitral valve disease (MR >2+ or MVA <1.5 cm2)
- •8. History of HMG-CoA reductase inhibitor hypersensitivity
- •9. Active liver disease
- •10. Muscular/neuromuscular disease
- •11. CPK >3 x upper limit of normal (>600 U/l)
- •12. Renal impairment (creatinine >200 umol/l)
- •13. Women contemplating pregnancy within next 5 years
- •14. Pregnant/breast-feeding women
- •15. Women of childbearing potential not using appropriate contraception
- •16. Use of cyclosporine
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