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Duration Between Drainage and Ureteroscopic Lithotripsy

Not Applicable
Completed
Conditions
Renal Stone
Ureter Stone
Ureteric Obstruction
Registration Number
NCT06101563
Lead Sponsor
Mansoura University
Brief Summary

This study will be conducted to compare early (seven days) versus delayed (14-21 days) definitive ureteroscopic lithotripsy after initial drainage for obstructing ureteral or renal stones associated with infection.

Detailed Description

All the study participants will be monitored during the early post-operative period for post-operative pain and complications. The rate and grade of reported complications will be determined according to modified Dindo-Clavian grading system. After ensuring safe status for discharge, all patients will be reassessed at the outpatient department after 4 weeks by NCCT to assess stone free status.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
96
Inclusion Criteria
  1. Obstructing ureteral or renal stone <20 mm.
  2. Associated clinical evidence of acute upper urinary tract infection based on systemic inflammatory response syndrome (SIRS).
Exclusion Criteria
  1. History of endoscopic instrumentation to the urinary tract in the last 4 weeks prior to presentation.
  2. Bilateral obstructed kidneys necessitating bilateral drainage.
  3. Associated emphysematous pyelonephritis or perinephric abscess.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Percentage of postoperative infectious complications in treatment groups30 days

Difference in post-URS infectious complications between the study groups. infectious complications are defined as presence of urinary tract infection with one of the following findings: - Body temperature more than 38.3C or below 36C. - Tachycardia (\>90/minute). - Respiratory rate more than 20/minute. - Disturbed mental status. - Systolic blood pressure \< 90 mmHg \& mean arterial pressure \< 70 mmHg or systolic blood pressure decrease \< 40 mmHg. - WBC \>12,000 or \<4,000.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Urology and Nephrology Center

🇪🇬

Mansoura, Egypt

Urology and Nephrology Center
🇪🇬Mansoura, Egypt

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