Association Between Stroke and Adrenal Incidentalomas

Recruiting

• Conditions: Adrenal Incidentaloma; Stroke

• Registration Number: NCT05237817
• Lead Sponsor: Xuanwu Hospital, Beijing

Brief Summary

Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke. Stroke is a diseases which could cause of disability and death worldwide. In clinical practice, detailed information about the association between stroke and AIs is not available. In this study, the investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.

Detailed Description

Background:

Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke . The investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.

Objective:

To measure the association between stroke and levels of autonomous cortisol secretion in patients with AIs.

Design:

Part 1, Retrospective cohort study.

From April 1, 2021, to September 30, 2021, cohort patients with stroke were recruited in this study. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics were record.

Part 2, Prospective cohort study.

From Mar 1, 2022, to Feb 29, 2024, cohort patients with stroke plane to recruit in this study. All patient receive the plasma cortisol level after a 1-mg dexamethasone suppression test. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics would be record.

Study Timeline

• Status Verified: 2021-04
• Study Start: 2021-04-01
• Study First Submitted: 2021-11-01
• Study First Submitted QC: 2022-02-08
• Last Update Submitted: 2022-02-08
• Study First Posted: 2022-02-14
• Last Update Posted: 2022-02-14
• Primary Completion: 2022-04-01
• Study Completion: 2029-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• stroke disease , such as Cerebral infarction、Intracerebral hemorrhage and Subarachnoid hemorrhage.

Exclusion Criteria

• presence of metastatic cancer;
• AIs smaller than 1 cm;
• nonadenoma lesions, such as myelolipomas,hemorrhages, and cysts;
• oral glucocorticoid treatment with more than single doses in the past 3 months;
• use of inhaled steroids or medication affecting dexamethasone metabolism;
• systemic estrogen treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence rate of Adrenal incidentalomas	5 years	Assess the standardised incidence rate of AIs in all patients with stroke
Plasma cortisol level	5 years	Plasma cortisol level after a 1-mg dexamethasone suppression test

Secondary Outcome Measures

Name	Time	Method
Diameter of Adrenal incidentalomas	5 years	Maximal axial diameter of adrenal incidentalomas by computed tomography scan; Millimetre as a metric unit of length in this study

Trial Locations

Locations (1)

Hao Yan; 🇨🇳 Beijing, China