A Randomized Clinical Trial on Hemoglobin Dose and Patient Matching
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anemia
- Sponsor
- Haukeland University Hospital
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Hemoglobin Concentration Change
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
The aim of this study is to evaluate whether the targeted hemoglobin increment (2 grams per decilitre) in the patient can be predicted from the hemoglobin dose/weight of the blood bag transfused. In the test group, the hemoglobin dose needed will be calculated, whereas in the control group, the prescribed number of red cell units will be transfused.
Hypothesis: By matching the hemoglobin dose to the individual needs of the patient the investigators will reduce the total usage of red cell concentrates.
Detailed Description
This is a randomized clinical study on hemoglobin dose and patient matching. The aim of the study is to evaluate whether the targeted hemoglobin increment (2 grams per decilitre) in the patient can be predicted from the hemoglobin dose/weight of the blood bag transfused. In the test group, the hemoglobin dose needed will be calculated, whereas in the control group, the prescribed number of red cell units will be transfused.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients receiving red cell transfusions or expected to receive one or more red cell transfusions
- •Patients over 16 years of age
- •Patients for whom height and weight information is available
- •Patients who have consented to participate
Exclusion Criteria
- •Patients who are hemodynamically unstable (ongoing bleeding or hemolysis)
- •Patients with a known hemolytic anemia (congenital or acquired)
- •Patients with a positive Direct Antiglobulin Test (DAT)
- •Patients for whom informed consent has not been obtained
- •Patients where the hemoglobin concentration increment target is above 2g/dl.
- •Patients with auto- or alloantibodies against RBCs (red blood cells)..
Outcomes
Primary Outcomes
Hemoglobin Concentration Change
Time Frame: Measurements of hemoglobin concentration taken from 30 min to 24hours after transfusion (earliest observation recorded)
The change in hemoglobin concentration after transfusion was recorded. The change is defined as hemoglobin (g/dl) after transfusion minus hemoglobin (g/dl) before transfusion.