Expectancies and pain modulatio
Recruiting
- Conditions
- Pain, expectations<br />Pijn, verwachtingen
- Registration Number
- NL-OMON19877
- Lead Sponsor
- eiden University
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 114
Inclusion Criteria
1.Healthy male and female participants
2.Between 18 and 35 years old
Exclusion Criteria
1.Refusal to provide written informed consent
2.Severe somatic or psychological morbidity (e.g. cardiovascular diseases, chronic pain or DSM-V psychiatric disorders) that would adversely affect participant’s safety or that might interfere with the study protocol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary study outcome is the difference in pressure pain thresholds (which will be determined by averaging 3 pressure pain threshold determinations following validated protocols) in combination with the cold pressor test compared to the determination without the cold pressor test. These difference scores will be compared between the three groups: a analgesia group in which participants receive positive verbal suggestions, a hyperalgesia group in which participants receive negative verbal suggestions and a control group in which participants receive no verbal suggestions.
- Secondary Outcome Measures
Name Time Method Secondary analyses will be conducted to examine sex differences in the role of expectations on CPM, the relationship between CPM and cognitive inhibition, and the effects of expectancy manipulation on other outcome parameters (e.g., pain ratings, psychophysiological assessments of heart rate and skin conductance levels and subjective stress). Pain and subjective stress levels will be assessed using 0-10 cm visual analog scales. In addition, the possible influence of psychological parameters on outcomes will be explored.