CTIS2022-502986-92-00
Recruiting
Phase 1
Anticoagulant therapy in patients with atrial fibrillation after surgical closure of the left atrial appendage: a randomized non-inferiority trial (The ATLAAC trial)
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Atrial fibrillation
- Sponsor
- Odense University Hospital
- Enrollment
- 1220
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 years, Previously undergone any type of cardiac surgical procedure including any type of surgical left atrial appendage closure (use of any of the following techniques; amputation and suture closure, stapler closure, non\-amputating suture closure or closure with an approved surgical occlusion device (e.g. AtriClip)) according to the National Patient Register (NPR) or the Western Danish Heart Registry (WDHR) from January 1st 2010 till April 1st 2023, Documented history of paroxysmal, persistent, or permanent atrial fibrillation or atrial flutter according to the electronic patient record, Informed consent
Exclusion Criteria
- •Not receiving oral anticoagulant therapy (warfarin/DOAC), Patient specific conditions requiring OAC (e.g. mechanical valve, previous pulmonary embolism), Renal impairment (estimated glomerular filtration rate \< 30\), Allergy to contrast media, Pregnancy or breastfeeding
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
Phase 4
Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)Atrial FibrillationLeft Atrial Appendage AbsentAnticoagulant Adverse ReactionNCT06401616Odense University Hospital1,220
Completed
Not Applicable
Treatment of atrial fibrillation in patients with high sympathetic activity by pulmonary vein isolation in combination with renal denervation or pulmonary vein isolation only; an international randomized, controlled trial.Hypertensie en signalen van sympathische overactiviteitAtrial fibrillationhypertension10007521NL-OMON47122Isala Klinieken100
Active, not recruiting
Phase 4
Management of Anticoagulant Therapy Monitored by an Implantable Device With Telecardiology in Patients With Acute Coronary Syndrome Associated With de Novo Atrial Fibrillation ArrhythmiaAtrial Fibrillation, Myocardial InfarctionNCT04276155Centre Hospitalier de PAU500
Completed
Not Applicable
Ablation of Sympathetic Atrial Fibrillatio<p>Atrial fibrillation, hypertension</p>10007521NL-OMON24798Isala klinieken, department of Cardiology, Zwolle145
Recruiting
Not Applicable
A new way of selecting atrial electrograms for ablatioAtrial fibrillationCardiovascular - Other cardiovascular diseasesACTRN12612001224819Prof Prash Sanders, Dr Anand Ganesan20