Clinical Value of DWI-ADC Matching in the Short-term Prognosis of Wilson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- UWDRS scales
研究概览
简要总结
In earlier studies, it was found that patients of Wilson disease with new diagnosed who only has neurological symptoms often had DWI hyper-intensity in brain MRI, which was more common in putamen and midbrain, indicating that the disease was in the acute stage. However, many patients had ADC hyper-intensity or hypo-intensity at the same time, and the two different signals represented different disease processes from an imaging perspective. The former indicating T2 penetration effect, and the latter represents diffusion limitation, which indicating the presence of local inflammation, edema, etc. Whether the signal changes of these two different matching modes have guiding significance for the early de-copper treatment for WD, one is the core point of our study. We hope to exploring the predictive value about DWI-ACD signal matching for symptoms changes in the earlier time of de-copper treatment through this study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients had been previously diagnosed with WD who both had DWI hyper-intensity and ADC hyper-intensity or hypo-intensity at the same time；
- •Patients who accept de-copper treatment in hospitalization for 4 weeks or more.
排除标准
- •Patients who only with liver injury;
- •Severe complications;
- •Combined with other diseases.
结局指标
主要结局
UWDRS scales
时间窗: Before and 4 weeks after treatment
It is used to evaluate the changes of patients' nervous system symptoms
24h urine copper
时间窗: Before and 4 weeks after treatment
used to evaluate the changes of patients' nervous system symptoms
次要结局
- Semi-quantitative brain MRI score(Before de-copper treatment)
- ALT, AST and other liver function test(Before and 4 weeks after treatment)