Cerebral Reorganization in Schizophrenia

Not Applicable

Completed

• Conditions: Schizophrenia
• Interventions: Behavioral: Facial Affect Training- FAT; Behavioral: Treatment as usual; Behavioral: Brain Fitness & Brain Training- Posit Science

• Registration Number: NCT01781000
• Lead Sponsor: University of Konstanz

Brief Summary

The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia

Detailed Description

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Study Timeline

• Study Start: 2011-12
• Study First Submitted: 2013-01-22
• Study First Submitted QC: 2013-01-29
• Study First Posted: 2013-01-31
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-03
• Last Update Posted: 2014-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Clinical diagnosis of schizophrenia and disorders with psychotic features
• Intact auditory perception
• Intact visual perception

Exclusion Criteria

• Mental retardation
• Age over 60
• Insufficient German language knowledge

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Facial affect discrimination training	Facial Affect Training- FAT	Behavioral: Facial Affect Training- FAT
Treatment as usual	Treatment as usual	standard treatment/rehabilitation protocol of schizophrenia ward
Auditiory verbal discrimination training	Brain Fitness & Brain Training- Posit Science	Brain Fitness \& Brain Training- Posit Science

Primary Outcome Measures

Name	Time	Method
change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations	baseline, post-intervention (after 4 weeks), 3-months follow-up

Secondary Outcome Measures

Name	Time	Method
change from baseline in global functioning (GAF score) at 4 weeks and 3 months	baseline, post-intervention, 3-months follow-up

Trial Locations

Locations (1)

University of Konstanz; 🇩🇪 Konstanz, Baden Württemberg, Germany