Effectiveness of lactase enzyme in subjects with lactase non-persistence

Completed

• Conditions: Adult-type hypolactasia; Nutritional, Metabolic, Endocrine; Lactose intolerance

• Registration Number: ISRCTN55840353
• Lead Sponsor: Oy Verman Ab (Finland)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05-19
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

1. Students from medical university with previously confirmed lactase non-persistent genotype (C/C-13910), aged 17 - 26 years, either sex
2. Students are included into study regardless of previous diseases, gastrointestinal symptoms, either connected or not with milk intake
3. All subjects will be fasting overnight before study and will be asked to avoid lactose content products 2 days before the study
4. Subjects will be asked to avoid lactose-containing food during 3 hours after the milk load with lactase enzyme or placebo

Exclusion Criteria

1. Inability or refusal to sign informed consent
2. Students younger or older than age of study group

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Five symptoms connected to lactose intolerance will be estimated by using the scale of severity where 1 is the minimal severity and 10 is maximum. Zero means no symptom. Subjects will fill in the table of severity of symptoms before intervention, 1 hour, 2 hours and 3 hours after the intervention and the rest of day after lunch.

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures