NCT01442402终止不适用
Impact of APOL1 Gene Variants in African American Kidney Transplant Recipients: A Study of Clinical Outcomes and Molecular Mechanisms
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Allograft survival
研究概览
简要总结
Aim 1:
Determine if there is an association between the APOL1 risk variants and allograft survival and function in African Americans
Aim 2:
Determine if there is an association between the presence of APOL1 risk variants in an African American kidney transplant recipient and the risk of recurrent disease
Aim 3:
Investigate mechanisms of APOL1 associated kidney disease by prospectively following African American kidney transplant recipients throughout their clinical course.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •self-reported African American
- •18 years or older
- •kidney transplant within 12 years
- •Inclusion Criteria for patients with recurrent disease:
- •self-reported African American
- •18 years or older
- •kidney transplant within 12 years
- •recurrent or de novo glomerular disease on allograft kidney biopsy
- •Inclusion Criteria for control group:
- •self-reported African American
- •18 years or older
- •kidney transplant within 12 years
- •end stage kidney disease due to glomerular nephritis, clinically diagnosed or by native kidney biopsy
- •Exclusion Criteria for control group:
- •clinical evidence of recurrent disease (presence of proteinuria, hematuria, Creatinine >2)
- •Inclusion Criteria:
- •self-reported African American
- •18 years or older
- •scheduled living kidney transplant
排除标准
- 未提供
结局指标
主要结局
Allograft survival
时间窗: year 1, 3, 5
次要结局
- Allograft function as measured by serum creatinine(creatinine levels at year-1, year-3 and year-5)
研究者
Anil K. Chandraker, MD
Medical Director of Renal Transplantation
Brigham and Women's Hospital
研究点 (1)
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