Usefulness of Pro-adrenomedullin (MR proADM)as a Predictor of Outcome in Acute Exacerbations of COPD Visiting the Emergency Room
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 370
- 试验地点
- 4
- 主要终点
- composite outcome measure
研究概览
简要总结
The purpose of this study is to determine whether pro-adrenomedullin (Mr proADM)in addition to clinical evaluation is effective to predict outcome of acute exacerbations of COPD patients visiting the emergency room(ER).
详细描述
Acute exacerbation of COPD (AECOPD)are usual and frequent cause of admission in emergency room (ER). No validated clinical or biological predictor of evolution are available.
The main objective is to determine the prognosis value of Mr proADM in addition to the clinical risk stratification for AE COPD patients in ER.
Patients presenting with a AECOPD diagnosis in ER will have a blood sample collected and freezed at their admission. Mr proADM will be assessed at the end of the study. Clinicians in charge of patients will not have the result during the management of their patients. This study implies no change in the patients' management.
Data related to the patients'demographic,current exacerbation and basic COPD characteristics will be collected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients > 40 years old
- •Acute exacerbation of COPD
排除标准
- •Medico social conditions not allowing home discharge
- •Other causes of Dyspnea: Pneumothorax, pulmonary embolism, pulmonary oedema, lung cancer
- •Pneumonia on chest ray
- •acute respiratory distress requiring immediate ICU transfer
结局指标
主要结局
composite outcome measure
时间窗: at Day 30
Death, subsequently transfer to ICU, relapse, need to be ventilated after 24 hours of their admission in ER
次要结局
- composite outcome(at Day 7 of ER admission)
- correlation between Mr proADM and patients Severity(at Day 7 and Day 30 of ED admission)