The Influence of Type of Anesthesia on Postoperative Pain After Laparoscopic Colorectal Cancer Surgery: Multi-center Prospective Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 468
- 试验地点
- 3
- 主要终点
- Postoperative 24 h opioid consumption
研究概览
简要总结
The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with propofol and remifentanil, while the other half will be anesthetized with sevoflurane and remifentanil during the surgery. The investigators will measure opioid consumption and pain score in the acute postoperative phase.
详细描述
Previous studies showed that patients receiving total intravenous anesthesia (TIVA) with propofol are associated with less postoperative pain and less opioid consumption compared with inhalation anesthesia. However, some studies showed conflicting results. In colorectal surgery, there are only retrospective studies that showed the analgesic effect of TIVA and inhalation anesthesia. The investigators designed a multi-center prospective randomized controlled trial and hypothesized that TIVA with propofol would be associated with reduced postoperative opioid consumption and less postoperative pain compared with sevoflurane in laparoscopic colorectal cancer surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient scheduled for elective laparoscopic colorectal cancer surgery
排除标准
- •Conversion from laparoscopic to open surgery
- •Allergy to anesthetics and analgesics
- •Previous abdominal surgery
- •Chronic pain
- •Chronic analgesic usage
研究组 & 干预措施
Inhalation anesthesia
Patients are anesthetized with sevoflurane and remifentanil infusion for maintenance of anesthesia during the surgery
干预措施: Sevoflurane (Drug)
Total intravenous anesthesia
Patients are anesthetized with target-controlled intravenous infusion of propofol and remifentanil infusion for maintenance of anesthesia during the surgery
干预措施: Propofol (Drug)
结局指标
主要结局
Postoperative 24 h opioid consumption
时间窗: 24 hours after the surgery
Cumulative opioid consumption for pain control 24 hours after the surgery
次要结局
- Postoperative 48 h opioid consumption(48 hours after the surgery)
- Numerical rating scale (NRS)(24 and 48 hours after the surgery)
研究者
Jin-Tae Kim
Professor (full)
Seoul National University Hospital