The Influence of Type of Anesthesia on Postoperative Pain After Laparoscopic Colorectal Cancer Surgery: Multi-center Prospective Randomized Controlled Study
Overview
- Phase
- N/A
- Intervention
- Sevoflurane
- Conditions
- Colo-rectal Cancer
- Sponsor
- Seoul National University Hospital
- Enrollment
- 468
- Locations
- 3
- Primary Endpoint
- Postoperative 24 h opioid consumption
- Status
- Active, Not Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with propofol and remifentanil, while the other half will be anesthetized with sevoflurane and remifentanil during the surgery. The investigators will measure opioid consumption and pain score in the acute postoperative phase.
Detailed Description
Previous studies showed that patients receiving total intravenous anesthesia (TIVA) with propofol are associated with less postoperative pain and less opioid consumption compared with inhalation anesthesia. However, some studies showed conflicting results. In colorectal surgery, there are only retrospective studies that showed the analgesic effect of TIVA and inhalation anesthesia. The investigators designed a multi-center prospective randomized controlled trial and hypothesized that TIVA with propofol would be associated with reduced postoperative opioid consumption and less postoperative pain compared with sevoflurane in laparoscopic colorectal cancer surgery.
Investigators
Jin-Tae Kim
Professor (full)
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Adult patient scheduled for elective laparoscopic colorectal cancer surgery
Exclusion Criteria
- •Conversion from laparoscopic to open surgery
- •Allergy to anesthetics and analgesics
- •Previous abdominal surgery
- •Chronic pain
- •Chronic analgesic usage
Arms & Interventions
Inhalation anesthesia
Patients are anesthetized with sevoflurane and remifentanil infusion for maintenance of anesthesia during the surgery
Intervention: Sevoflurane
Total intravenous anesthesia
Patients are anesthetized with target-controlled intravenous infusion of propofol and remifentanil infusion for maintenance of anesthesia during the surgery
Intervention: Propofol
Outcomes
Primary Outcomes
Postoperative 24 h opioid consumption
Time Frame: 24 hours after the surgery
Cumulative opioid consumption for pain control 24 hours after the surgery
Secondary Outcomes
- Postoperative 48 h opioid consumption(48 hours after the surgery)
- Numerical rating scale (NRS)(24 and 48 hours after the surgery)