The Effect of a Group Exercise Intervention on Muscle Activation Patterns in People With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Hamstrings co-activation (Hamstrings PC2)
研究概览
简要总结
This will be a clinical trial of a standardized group exercise intervention, Les Mills Thrive, and determine if it alters muscle activation patterns and improves strength, balance, and symptoms in those with knee osteoarthritis (OA). Muscle activation patterns will be assessed using surface electromyography, strength will be assessed using isokinetic dynamometry, balance will be measured using the Community Balance and Mobility Scale (CB&M), and symptoms and typical activity will be measured using two questionnaires: the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Physical Activity Scale for the Elderly (PASE). These outcome measures will be measured at baseline and after a 12-week group exercise intervention (Les Mills Thrive) for 42 older adults with knee OA. Results of this study will be disseminated via a report to Les Mills International, in community presentations, at relevant academic (e.g. Osteoarthritis Research Society International (OARSI) annual conference) and industry (e.g. Medical Fitness Association annual meeting) conferences, in an academic journal publication (e.g. Arthritis Care & Research), and through press releases or other media publications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants must have received a diagnosis of knee OA from a physician and/or meet the American College of Rheumatology Clinical Classification Criteria for Osteoarthritis of the knee. The American College of Rheumatology criteria specify that a participant needs to have pain and fulfill three of the following six items: 1) aged 50 years or older, 2) no early morning stiffness or morning stiffness less than 30 minutes, 3) crepitus, 4) bony tenderness, 5) bony enlargement, 6) no palpable warmth
- •They must pass the Get Active Questionnaire to ensure that they are safe to begin an exercise program (determined via recruitment email).
排除标准
- •i) severe knee trauma, knee surgery, or intraarticular knee joint injections in the previous six months, ii) active synovitis, iii) concurrent neurological (i.e. Parkinson's disease, Alzheimer's dementia, or polyneuropathy), endocrine (i.e., diabetes mellitus) and/or vestibular disorders which may affect balance, iv) chronic disease that may put them at risk during the exercise classes (i.e., history of heart failure, stroke, chronic obstructive lung disease), v) uncorrected visual impairment which may affect balance, or vi) an inflammatory rheumatic disease (i.e., rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and chronic reactive arthritis).
研究组 & 干预措施
Exercise program
Les Mills Thrive is a 45-minute class that consists of flexibility, strength, and coordination exercises designed to be delivered in a group fitness environment. Participants will have the option to attend group fitness classes in person, or do the exercise program at home on their own asynchronously, using recorded classes as guidance.
干预措施: Exercise (Behavioral)
结局指标
主要结局
Hamstrings co-activation (Hamstrings PC2)
时间窗: From baseline data collection to the end of the intervention at 12 weeks.
Surface electromyography (EMG) will be used to assess muscle activation patterns from the quadriceps and hamstrings. We will assess overall magnitude of activity as well as co-activation. These outcomes will be extracted from the EMG data using principal component analysis (PCA). PCA is a pattern recognition technique that extracts the main patterns in waveform data. It has previously identified patterns of quadriceps and hamstrings activity that are correlated with knee osteoarthritis progression. The second pattern extracted from hamstrings EMG waveforms (Hamstrings PC2) captures prolonged hamstrings activation (i.e. co-activation).
Quadriceps amplitude (Quadriceps PC1)
时间窗: From initial data collection to the end of treatment at 12 weeks
Surface electromyography (EMG) will be used to assess muscle activation patterns from the quadriceps and hamstrings. We will assess overall magnitude of activity as well as co-activation. These outcomes will be extracted from the EMG data using principal component analysis (PCA). PCA is a pattern recognition technique that extracts the main patterns in waveform data. It has previously identified patterns of quadriceps and hamstrings activity that are correlated with knee osteoarthritis progression. The first pattern extracted from quadriceps EMG waveforms (Quadriceps PC1) captures the overall magnitude (i.e. amplitude) of quadriceps activity.
Quadriceps co-activation ( Quadriceps PC2)
时间窗: From baseline data collection to the end of the intervention at 12 weeks.
Surface electromyography (EMG) will be used to assess muscle activation patterns from the quadriceps and hamstrings. We will assess overall magnitude of activity as well as co-activation. These outcomes will be extracted from the EMG data using principal component analysis (PCA). PCA is a pattern recognition technique that extracts the main patterns in waveform data. It has previously identified patterns of quadriceps and hamstrings activity that are correlated with knee osteoarthritis progression. The second pattern extracted from quadriceps EMG waveforms (Quadriceps PC2) captures prolonged quadriceps activity (i.e. co-activation).
Hamstrings amplitude (Hamstrings PC1)
时间窗: From baseline data collection to the end of the intervention at 12 weeks.
Surface electromyography (EMG) will be used to assess muscle activation patterns from the quadriceps and hamstrings. We will assess overall magnitude of activity as well as co-activation. These outcomes will be extracted from the EMG data using principal component analysis (PCA). PCA is a pattern recognition technique that extracts the main patterns in waveform data. It has previously identified patterns of quadriceps and hamstrings activity that are correlated with knee osteoarthritis progression. The first pattern extracted from hamstrings EMG waveforms (Hamstrings PC1) captures the overall magnitude (i.e. amplitude) of hamstrings activity.
次要结局
- Knee extensor strength(From baseline data collection until the end of the intervention at 12 weeks.)
- Symptoms (WOMAC)(From baseline data collection until after the 12 week intervention.)
- Physical activity(From baseline until after the 12 week intervention.)
- Balance (Community Balance & Mobility Scale)(From baseline data collection to the end of the intervention at 12 weeks.)
- Knee flexor strength(From baseline data collection until after the 12 week intervention.)
研究者
Gillian Hatfield
Associate Professor
University of the Fraser Valley