Predictors of Chronic Kidney Disease Among Type 2 Diabetic Patients in Assiut University Hospitals

Recruiting

• Conditions: Type 2 Diabetes With Renal Manifestations

• Registration Number: NCT05847400
• Lead Sponsor: Assiut University

Brief Summary

Predictors of Chronic Kidney Disease among Type 2 Diabetic Patients in Assiut University Hospitals.

Detailed Description

Globally, the total number of people with diabetes is estimated to increase from 415 million (8.8%) in 2015 to 642 million (10.4%) in 2040, with the largest alterations expected to occur in the urban population of low- to middle-income countries (LMICs)1. Of them, type 2 diabetes mellitus (T2DM) accounts for more than 90% of people with diabetes2,3. By 2040, the difference worldwide is projected to broaden, with 477.9 million affected people living in urban areas and 163.9 million in rural areas1. It has been postulated that the burden of diabetes and its complications in the LMICs may be contributed by the economic development and rapid urbanisation via increased caloric intake and the adoption of a sedentary lifestyle2,4,5. More importantly, the most striking demo graphic change to diabetes prevalence in global terms also seems to be related to the growth of the proportion of the elderly population6. Despite rates of diabetes-related complications such as CVDs decreasing significantly in the past two decades, it has not translated nearly as well as kidney complications7. Approximately 10% of deaths in people with T2DM are attributable to kidney failure8. It is well-established that diabetes-related chronic kidney disease (CKD) is the leading cause of end-stage kidney disease (ESKD) in T2DM patients worldwide9,10.

In our study, we aim to identify and classify patients attending diabetic outpatient clinic with both CKD and

Study Timeline

• Status Verified: 2023-04
• Study First Submitted: 2023-04-27
• Study First Submitted QC: 2023-05-05
• Last Update Submitted: 2023-05-05
• Study First Posted: 2023-05-06
• Last Update Posted: 2023-05-06
• Study Start: 2024-03-01
• Primary Completion: 2024-03-28
• Study Completion: 2024-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients with T2DM aged 18 years or older. For patients whom eGFR values < or =60 ml/min/1.73m2.

Patient with type 2 DM and ESRD on regular HD with duration less than 1 year

Exclusion Criteria

Having kidney transplantation incomplete data on glycemic control. Patients with type 2 DM and ESRD on regular HD with duration more than 1 year. Pregnant woman. Patients with advanced comorbides(cardiac, hepatic,

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
predictors of CKD among T2DM patients attending Assiut University Hospitals. To classify our patients into stages according to KDIGO guidelines	3 years	To identify predictors of CKD among T2DM patients attending Assiut University Hospitals.; To classify our patients into stages according to KDIGO guidelines

Secondary Outcome Measures

Name	Time	Method
the possible risk factors contributing to progessing CKD in T2DM patients.	3 years	To identify the possible risk factors contributing to progessing CKD in T2DM patients.

Trial Locations

Locations (1)

Assiut; 🇪🇬 Assiut, Egypt