Oxygen during activities in patients with lung scarring

Completed

• Conditions: Fibrotic lung diseases; Respiratory

• Registration Number: ISRCTN16427067
• Lead Sponsor: Royal Brompton and Harefield NHS Foundation Trust (RB&HFT)

Brief Summary

2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30170904

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-03-22
• Study Completion: 2017-12-31
• Last Update Posted: 14 January 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1.Patients with a diagnosis of idiopathic pulmonary fibrosis (IPF), or with another fibrotic ILD
2. Aged between 18 and 99 years
3. Patients whose oxygen saturation (SaO2) at rest on room air is =94% and falls<88% on a baseline 6MWT (performed as part of their routine assessment)
4. Patients with stable symptoms and treatment during the period of four weeks prior to being recruited into the study, including the two week run in period

Exclusion Criteria

1.Patients expected to change treatment over the time course of the study, and those meeting criteria for long term oxygen therapy, i.e. hypoxic at rest
2.Patients with connective tissue disease-associated ILD or with sarcoidosis with musculoskeletal/joint involvement/symptoms will be excluded due to the potential impact in relation to day-to-day mobility
3.Patients with significant communication or other locomotor difficulties, and/or severe co-morbidities
4.Current smokers in view of the potential risks associated with use of supplemental oxygen
5.Pregnancy
6.History of symptomatic ischaemic cardiac disease (exertion-induced chest pain)
7.Anaemia, Hb<10g/dl

Study & Design

• Study Type: Interventional
• Study Design: Not specified