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Clinical Trials/NCT06410963
NCT06410963
Active, not recruiting
Not Applicable

ReActivate: Physiotherapist Led Intervention for Adolescents and Young Adults With Musculoskeletal Pain; A Sequential Replicated and Randomized Single Case Experimental Design (SCED)

Örebro University, Sweden2 sites in 1 country35 target enrollmentSeptember 23, 2024

Overview

Phase
Not Applicable
Intervention
No treatment waiting period
Conditions
Chronic Pain
Sponsor
Örebro University, Sweden
Enrollment
35
Locations
2
Primary Endpoint
Activity engagement change
Status
Active, not recruiting
Last Updated
18 days ago

Overview

Brief Summary

Recurrent or persistent musculoskeletal pain is an alarmingly common problem among adolescents, in Sweden as well as globally. Pain often co-occur with and psychological distress and have both been shown to be predictors of sustained problems in adulthood. Adequate treatment early on in the development of problems has been shown important in order to decrease the risk of sustained problems in adulthood but available treatments have only modest effects. There is thus a need for treatment development, not in the least for (secondary) preventative purposes. The aim of this project is therefore to develop an evidence based and cost-effective secondary preventative intervention. Specifically, this project aims to develop and test a physiotherapist led treatment for adolescents with recurrent or persistent musculoskeletal pain and based upon graded exposure to physical activity and reactivation.

Detailed Description

See description of arms and intervention.

Registry
clinicaltrials.gov
Start Date
September 23, 2024
End Date
December 1, 2026
Last Updated
18 days ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Sponsor
Örebro University, Sweden
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Age 12-25
  • Persistent (consistently or weekly recurrent) musculoskeletal pain problems for ≥3 months, with pain intensity ≥2 on a numeric rating scale 0-6 (0=not at all, 6=to a great extent)
  • Presence of avoidance behaviour and/or or worry about symptoms/problems, ≥1 on a numeric rating scale 0-6 (0=not at all, 6=to a great extent); \> 50 on at least one activity of the PHODA.
  • Swedish speaking and able to fill out questionnaires

Exclusion Criteria

  • Serious/malignant disease
  • Participation in other rehabilitation program
  • Severe mental health problems
  • Substance abuse
  • Severe learning disabilities

Arms & Interventions

No treatment waiting period

Participants are randomized to a 7, 14 or 21 day waiting period. Daily measurements are collected throughout this period.

Reactivate

Reactivate treatment. Daily measurements are collected throughout treatment.

Intervention: Reactivate

Outcomes

Primary Outcomes

Activity engagement change

Time Frame: repeated daily through phase A (randomly assigned to be 7, 14 or 21 days) and treatment phase B (9-11 weeks). Total time frame of assessment is 12 weeks (84 days). 7 days assessment 6 months after terminated intervention

Change in self-rated activity engagement. Numerical Rating Scale, range 0-6 (1 question: lower values, worse outcome, 1 question: Lower values, better outcome )

Symptom distress change

Time Frame: repeated daily through phase A (randomly assigned to be 7, 14 or 21 days) and treatment phase B (9-11 weeks). Total time frame of assessment is 12 weeks (84 days). 7 days assessment 6 months after terminated intervention.

Change in self-rated distress about symptoms. Numerical Rating Scale, range 0-6 (3 questions, higher values, worse outcome)

Secondary Outcomes

  • Change in psychological distress(repeated daily through phase A (randomly assigned to be 7, 14 or 21 days) and treatment phase B (9-11 weeks). Total time frame of assessment is 12 weeks (84days). 7 days assessment 6 months after terminated assessment.)
  • Fear of Pain Questionnaire Children Short-form (FOPQ-C SF) change(baseline, after treatment phase B (12 weeks), 6 months after terminated intervention)
  • Functional Disability Inventory (FDI) change(baseline, after treatment phase B (12 weeks), 6 months after terminated intervention)
  • Center of Epidemiological Studies Depression Scales for Children (CES-DC) change(baseline, after treatment phase B (12 weeks), 6 months after terminated intervention)
  • The Pediatric Quality of Life Acute version (PedsQL) PedsQL™(baseline, after treatment phase B (12 weeks), 6 months after terminated intervention)
  • The Photograph Series of Daily Activities for youth (PHODA) change - short(First session after baseline (randomly assigned to be 7, 14 or 21 days), after treatment phase B (12 weeks))
  • Pain change(repeated daily through phase A (randomly assigned to be 7, 14 or 21 days) and treatment phase B (9-11 weeks). Total time frame of assessment is 12 weeks (84days). 7 days assessment 6 months after terminated assessment.)

Study Sites (2)

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