Selenium Concentration in Blood and Inflammatory Activity in Critically Ill Childre
Not Applicable
- Conditions
- ndernutrition.
- Registration Number
- RBR-2wz5kq
- Lead Sponsor
- niversidade Federal de São Paulo - UNIFESP
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Children admitted to the Pediatric Intensive Care Unit with a diagnosis of systemic inflammatory response syndrome, sepsis, septic shock or multiple organ systems.
Exclusion Criteria
Neonates, children with chronic renal or hepatic impairment, and suspected inborn error of metabolism.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of requency and risk factors associated with low plasma selenium and glutathione peroxidase activity in red blood cells of critically ill children on admission and on the fifth day of hospitalization in the pediatric intensive care unit, considering the nutritional status and intensity of the inflammatory response. Nutritional status will be assessed by age, weight, height and their relationship on admission. The intensity of the inflammatory response will be assessed by measurement of plasma C-reactive protein on admission and on the fifth day of hospitalization. As a result, it is expected that patients with impaired nutrition (malnutrition) on admission and more intense inflammatory response during hospitalization have a lower plasma selenium concentration compared to patients without malnutrition and lower inflammatory response.
- Secondary Outcome Measures
Name Time Method o secundary outcomes.