Berlin-Brandenburg Pregnancy Cohort

Recruiting

• Conditions: Preeclampsia; Pregnancy Complications; Diabetes Mellitus in Pregnancy

• Registration Number: NCT03313024
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the translation of the uteroplacental syndrome into a maternal syndrome, considered in the multifactorial pregnancy disorder preeclampsia, will be investigated. Immune cell subtypes are causally involved in the formation and translation of preeclampsia by inducing an endothelial dysfunction which leads to cardiovascular damage.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-26
• Study First Submitted: 2017-10-13
• Study First Submitted QC: 2017-10-13
• Study First Posted: 2017-10-18
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-13
• Last Update Posted: 2018-08-14
• Primary Completion: 2027-10
• Study Completion: 2027-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 1580

Inclusion Criteria

• healthy pregnant women after giving informed consent
• pregnant with diagnosis of preeclampsia, gestational hypertension or gestational diabetes

Exclusion Criteria

• infections
• alcohol and drug abuse
• manifest and chronic diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
T cell population content at the time of preeclampsia diagnosis compared to controls and verified by flow cytometry	at the time of preeclampsia diagnosis compared to controls at the same time point in pregnancy

Trial Locations

Locations (1)

Experimental and Clinical Research Center (ECRC); 🇩🇪 Berlin, Germany