Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 4
- 主要终点
- Cardiac Output
研究概览
简要总结
Interventional Trial to determine the Effect of different PEEP levels on Cardiac output and right-ventricular function in mechanically ventilated children < 5 years of age with congenital heart disease.
详细描述
Different PEEP-levels will be applied during invasive mechanical ventilation to describe Cardio-pulmonary interactions in children with congenital heart disease (CHD). An additional trial with the same study protocol is planned in a cohort of children with primarily pulmonary disease without CHD after completion of this trial. Esophageal pressure-monitoring, Ultrasound, respiratory mechanics and electrical impedance tomography will be used
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 1 Day 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •invasive mechanical ventilation
- •congenital heart disease (biventricular anatomy)
排除标准
- •univentricular hearts
研究组 & 干预措施
ventilated children
Application of different PEEP-levels during invasive mechanical ventilation
干预措施: PEEP (Procedure)
结局指标
主要结局
Cardiac Output
时间窗: 1 year
change in CO during intervention
次要结局
- respiratory mechanics(1 year)
- Global Strain RV (%/sec)(1year)
- TAPSV (cm/s)(1year)
- TAPSE (cm)(1 year)
- Lung Compliance (ml/Min/kg)(1year)
- EIT(1year)
- Esophageal Pressure (mbar)(1year)
研究者
Jan Clausen
Dr. med. / MD
Charite University, Berlin, Germany