STUDY OF IMAGING MARKERS IN THE VERY EARLY STAGES OF DEMENTIA AMONG RETIRED RURAL FARM IN THE GIRONDE AND PARTICIPATING IN THE AMI COHORT EPIDEMIOLOGY: A LONGITUDINAL STUDY.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 304
- 试验地点
- 2
- 主要终点
- Measures of volume and diffusion parameters in the gray matter (hippocampus and cingular posterior cortex)
研究概览
简要总结
It is now acknowledged that Alzheimer's disease is characterized by a long period of pathophysiological change. Developing new strategies to achieve diagnoses as early as possible has become a major goal for therapies aimed at slowing the progression of this disease. While diagnoses currently rely principally on clinical neuropsychology, the typical diagnostic criteria of NINCDS-ADRDA are inapplicable in the early stage of the disease. The goal of our project is to identify very early imaging markers for Alzheimer's disease among patients with no report of cognitive difficulties. In order to achieve this goal, we propose a longitudinal study in an elderly population cohort.
详细描述
The AMImage2 project that follows AMImage1 and MRI-3C consists of an imaging study in association with longitudinal epidemiologic cohorts (AMI and 3C). The first objective is to investigate the association between the evolution of imaging markers and the evolution of cognitive performance in normal and pathological aging. This objective will be conducted among subjects having already participated in AMImage1, thereby permitting the longitudinal study of MRI data. An MRI exam will also be proposed to 100 subjects (members of the AMI and 3C cohorts) in order to provide a third wave of MRI (for a longer-term MRI follow-up) or a second one for the participants who only had one MRI exam in the AMImage project. Our second objective is cross-sectional and will study the imaging parameters of subjects presenting signs of cognitive decline over the previous 4 years (through the follow-up conducted in the AMI cohort). Finally, an additional objective will consist in a comparison between two populations very contrasted in terms of cognitive reserve: AMI (very low education level in rural area) and 3C (higher level of education in urban area).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least 65 years old
- •Be retired from agricultural profession
- •live in rural area in Gironde (France)
排除标准
- •Lefthanded
- •having a dementia (MMSE < 13)
- •Having a vascular cerebral accident
- •Parkinson disease
- •RMI exclusion criteria
- •[18F]-FDG PET SCAN exclusion criteria
- •Poor health condition does not allowing transport to neuroimaging service
研究组 & 干预措施
Participant from AMI cohort
干预措施: Neuroimaging (Other)
Participant from 3Ccohort
干预措施: Neuroimaging (Other)
结局指标
主要结局
Measures of volume and diffusion parameters in the gray matter (hippocampus and cingular posterior cortex)
时间窗: Inclusion (Day 0)
次要结局
- Performance on neuropsychological and daily life cognitive tests(Everyday up to Day 7 after inclusion)