Skip to main content
Clinical Trials/CTRI/2025/07/089970
CTRI/2025/07/089970Not yet recruitingNot Applicable

Point of Care Ultrasound-guided Diamond Forrester Phenotyping of Patients Presenting in Shock to the Emergency Department-A prospective Observational study

Jawaharlal Institute of Postgraduate Medical Education and Research1 site in 1 country96 target enrollmentStarted: July 11, 2025Last updated:

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
96
Locations
1
Primary Endpoint
The study will give a better understanding of haemodynamic phenotypes in hypoperfusive patients. It will provide insight into dynamic shifts in phenotypes during shock resuscitation. This will help us to better tailor resuscitation

Study Overview

Brief Summary

Shock resuscitation is one of the most challenging modalities faced by acute care providers, especially during the early hours of resuscitation. Shock, or hypoperfusion state, is a physiological derangement that needs to be corrected appropriately in a time-sensitive manner to prevent mortality and morbidity. The cornerstone in the management of shock is based on assessing the type of shock and resuscitating with fluids, vasopressors, and inotropes.Resuscitation is based on determining whether the patient has hypovolemic, distributive, cardiogenic, or obstructive shock. In recent decades, point-of-care ultrasound (POCUS) has been used during early resuscitation to identify the type of shock and augment the resuscitation process. Despite these advancements and regularly updated international treatment guidelines, the optimal therapeutic approach is controversial, especially with regard to intravenous (IV) fluids. It has been observed that even though patients are initially fluid responsive when resuscitated with IV fluids, may later show signs of venous congestion. The coexistence of venous congestion in more than 50% of patients who were fluid responsive has been reported. A personalised resuscitation approach has been suggested based on patients’ physiological derangement.

Point of Care-guided profiling uses dichotomised Velocity time integral (VTI) and Venous Excess Ultrasound (VEXUS) to classify these phenotypes. Our current study will use one more alternative surrogate for both to add to accuracy.

Study Design

Study Type
Observational

Eligibility Criteria

Ages
18.00 Year(s) to 99.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • One group -Adult undergoing fluid resuscitation in Emergency Department.

Exclusion Criteria

  • Patients with valvular pathologies or prosthetic valve Patients with Persistent arrhythmias Patients in whom atleast two serial measurements could not be performed Patients with poor transthoracic or abdominal window Pregnant Females.

Outcomes

Primary Outcomes

The study will give a better understanding of haemodynamic phenotypes in hypoperfusive patients. It will provide insight into dynamic shifts in phenotypes during shock resuscitation. This will help us to better tailor resuscitation

Time Frame: Total time for one sample size is 4 hours as study involves assessing hemodynamics of shock patient every 30 minutes for 4 hours after presenting to Emergency Department

interventions.

Time Frame: Total time for one sample size is 4 hours as study involves assessing hemodynamics of shock patient every 30 minutes for 4 hours after presenting to Emergency Department

Secondary Outcomes

  • To evaluate the correlation between phenotypic(shifts during resuscitation among various types of shock using Doppler starlings curve.)

Investigators

Sponsor Class
Government medical college
Responsible Party
Principal Investigator
Principal Investigator

Manjupriya G

JIPMER Puducherry

Study Sites (1)

Loading locations...

Similar Trials