跳至主要内容
临床试验/CTRI/2025/07/089970
CTRI/2025/07/089970尚未招募不适用

Point of Care Ultrasound-guided Diamond Forrester Phenotyping of Patients Presenting in Shock to the Emergency Department-A prospective Observational study

Jawaharlal Institute of Postgraduate Medical Education and Research1 个研究点 分布在 1 个国家目标入组 96 人开始时间: 2025年7月11日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
96
试验地点
1
主要终点
The study will give a better understanding of haemodynamic phenotypes in hypoperfusive patients. It will provide insight into dynamic shifts in phenotypes during shock resuscitation. This will help us to better tailor resuscitation

研究概览

简要总结

Shock resuscitation is one of the most challenging modalities faced by acute care providers, especially during the early hours of resuscitation. Shock, or hypoperfusion state, is a physiological derangement that needs to be corrected appropriately in a time-sensitive manner to prevent mortality and morbidity. The cornerstone in the management of shock is based on assessing the type of shock and resuscitating with fluids, vasopressors, and inotropes.Resuscitation is based on determining whether the patient has hypovolemic, distributive, cardiogenic, or obstructive shock. In recent decades, point-of-care ultrasound (POCUS) has been used during early resuscitation to identify the type of shock and augment the resuscitation process. Despite these advancements and regularly updated international treatment guidelines, the optimal therapeutic approach is controversial, especially with regard to intravenous (IV) fluids. It has been observed that even though patients are initially fluid responsive when resuscitated with IV fluids, may later show signs of venous congestion. The coexistence of venous congestion in more than 50% of patients who were fluid responsive has been reported. A personalised resuscitation approach has been suggested based on patients’ physiological derangement.

Point of Care-guided profiling uses dichotomised Velocity time integral (VTI) and Venous Excess Ultrasound (VEXUS) to classify these phenotypes. Our current study will use one more alternative surrogate for both to add to accuracy.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 99.00 Year(s)(—)
性别
All

入选标准

  • One group -Adult undergoing fluid resuscitation in Emergency Department.

排除标准

  • Patients with valvular pathologies or prosthetic valve Patients with Persistent arrhythmias Patients in whom atleast two serial measurements could not be performed Patients with poor transthoracic or abdominal window Pregnant Females.

结局指标

主要结局

The study will give a better understanding of haemodynamic phenotypes in hypoperfusive patients. It will provide insight into dynamic shifts in phenotypes during shock resuscitation. This will help us to better tailor resuscitation

时间窗: Total time for one sample size is 4 hours as study involves assessing hemodynamics of shock patient every 30 minutes for 4 hours after presenting to Emergency Department

interventions.

时间窗: Total time for one sample size is 4 hours as study involves assessing hemodynamics of shock patient every 30 minutes for 4 hours after presenting to Emergency Department

次要结局

  • To evaluate the correlation between phenotypic(shifts during resuscitation among various types of shock using Doppler starlings curve.)

研究者

申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Manjupriya G

JIPMER Puducherry

研究点 (1)

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