Investigating the effect of PRP and mesenchymal stem cells on improving the motor function of stroke patients

Phase 1

Recruiting

Conditions: Stroke, not specified as haemorrhage or infarction
stroke.

Registration Number: IRCT20230208057351N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 15

Inclusion Criteria

Patients suffering from stroke for the first time
Patients who have had at least 6 months of stroke
Stroke patients in the age range of 40 to 70 years
Patients who are able to understand commands
Stroke patients with elbow flexor muscle spasticity 1 and above according to MMAS
Stroke patients whose upper limb function is in Brunnstrom stage 3

Exclusion Criteria

History of previous stroke or other central nervous system disorders that can lead to spasticity
Patients who have fixed elbow contracture
Patients who have had Botox injections in the elbow flexor muscle in the last year
The patient's lack of consent to continue participating in the study
Incidence of recurrent stroke during the study period
A systemic reaction to the treatment that makes it impossible to continue the investigation
Patients who have contraindications for PRP Therapy include: Platelet dysfunction syndrome, Critical thrombocytopenia, Hemodynamic instability, Septicemia, Corticosteroid injection within the last 1 month, Smoking, Fever or cancerous disease, especially of blood-forming cells or bone, Hb< 10 g/dl, Number of platelets less than 105 /µl, Local infection at the injection site

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Spasticity. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: Modified Modified Ashworh Scale (MMAS).;Motor recovery stage. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: Brunnstrom recovery stages table.;Active and passive Range of Motion (ROM) of elbow. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: A universal goniometer.

Secondary Outcome Measures

Name	Time	Method
Fascicle length. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography.;Pennation angle. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography.;Muscle thickness. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography.;Echo intensity. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography.