EUS Guided Cyanoacrylate Injection vs Endoscopic Variceal Band Ligation for Prevention of Rebleeding in Patients With Hepatocellular Carcinoma and Esophageal Variceal Bleeding

Active, not recruiting

• Conditions: Hepatocelular Carcinoma; EUS Guided Cyanoacrylate Injection; Endoscopic Variceal Band Ligation; Esophageal Variceal Bleeding

• Registration Number: NCT04918459
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-6-3
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Inclusion Criteria:<br><br> 1. Consecutive HCC patients with history of EV bleeding who underwent EUS guided<br> cyanoacrylate injection or variceal band ligation by EGD for secondary prophylaxis<br> to prevent EV rebleeding<br><br> 2. Age > 18 years<br><br>Exclusion Criteria:<br><br> 1. HCC patients with non-variceal upper GI bleeding<br><br> 2. HCC patients with history of EV bleeding who did not undergo further endoscopy for<br> secondary prophylaxis for EV rebleeding

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Death adjusted cumulative incidence of rebleeding at 30-day

Secondary Outcome Measures

Name	Time	Method
Death adjusted cumulative incidence of rebleeding at 90-day;Bleeding-free survival at 3 months and 6 months;Adverse events related to EUS-CYA or EGD-VBL for secondary prophylaxis;Mortality rate at 6 months