The Vaccination Cohort Study on: 1. Immunologic Protection after Vaccination of Immune-compromised Patients 2. Assessment of the Infection Rate after International Travel
Withdrawn
- Conditions
- Travellers vaccination10019815
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
All individuals, irrespective of age, sex and underlying illness visiting the Erasmus MC *vaccination and travel clinic* requiring travel related, medically indicated or voluntary vaccination(s)
Exclusion Criteria
No informed consent
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The antibody titer after vaccination of immune compromised patients compared to<br /><br>immunocompetent patients and the incidence of infectious diseases during travel</p><br>
- Secondary Outcome Measures
Name Time Method <p>1a The capability of naïve memory B cells to generate an<br /><br>antibody response after live, conjugated and polysaccharide vaccine dose<br /><br>increase in case of non-responders<br /><br>1b Dendritic cell function and antigen presentation properties<br /><br>1c CD8+ cytotoxic properties<br /><br>1d Waning effects of vaccines by the presence of a prolonged (i.e. after 6<br /><br>months) qualitative antibody response by detecting high affinitive IgG<br /><br>antibodies in serum as well as B-cell reactivation properties </p><br>