Effects of Exercise Intervention and Confounding Factors on Type II Diabetic Muscles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Relative sliding of muscles
研究概览
简要总结
The aim of the first year of this three-year plan is to analyze and compare the muscle quality of lower limb muscle (microcirculation, muscle performance and mechanical characteristics) and maximal aerobic exercise capacity in treadmill exercise tests for diabetic and non-diabetic cases. The hypotheses are:1) the muscle quality of lower limb muscle and maximal aerobic exercise capacity are different between participate with diabetic and non-diabetic, 2) the effect of the three-month aerobic exercise intervention or home exercise on the characteristics of the muscle quality are different , and 3) intrinsic factors (such as age, BMI, and HDL) and characteristics of specific FTO genes are influenced the training outcomes.
详细描述
Participants with diabetes will attend an 12-week aerobic exercise intervention or home exercise if the exercise test result of the maximum rate of oxygen consumption is fair or poor. Assessments will be taken before and after the training program, which including muscle strength, stiffness, quality, microcirculation and exercise capacity. Comparisons between the pre-training and post-training condition will be made for each groups. And the assessments also compare with the healthy control group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diabetes group: 1) Age between 30-70 years of old, 2) type 2 diabetes.
- •Healthy control group: 1) Age between 30-70 years of old, 2) without diabetes
排除标准
- •history of moderate-severe somatic or autonomic neuropathy, cardiovascular disease, preproliferative or proliferative retinopathy, and chronic renal failure
- •unable to perform the programs or assessments
- •other systematic diseases
研究组 & 干预措施
aerobic exercise group
This study will recruit qualified diabetic subjects according to their results of maximal aerobic exercise capacity (VO2max) and assign them into aerobic exercise or home exercise groups, based on their willingness. The aerobic exercise group will arranged to the supervised aerobic dance program, it's consisted of 50 mins per session, 3 sessions per week and last for 3 months.
干预措施: supervised aerobic exercise or home-based aerobic exercise (Behavioral)
home exercise group
This study will recruit qualified diabetic subjects according to their results of maximal aerobic exercise capacity (VO2max) and assign them into aerobic exercise or home exercise groups, based on their willingness.The home exercise group will give the exercise recommendation based on ACSM's guideline, and it's consisted of 50 mins per session, 3 sessions per week and last for 3 months.
干预措施: supervised aerobic exercise or home-based aerobic exercise (Behavioral)
health control group
This study will recruit subjects without type 2 diabetes and the age matched to the diabetes groups.
干预措施: supervised aerobic exercise or home-based aerobic exercise (Behavioral)
结局指标
主要结局
Relative sliding of muscles
时间窗: Change from Baseline muscle quality at 3 months
B mode sonography was used, units on mm/s
muscle microcirculation
时间窗: Change from Baseline muscle quality at 3 months
Near-infrared spectroscopy was used to measure oxygen saturation on muscle, units on percentage
muscle strength of knee extensor and plantarflexor
时间窗: Change from Baseline functional performance at 3 months
Dynamometer was used to measure muscle strength, units on kilograms
maximum rate of oxygen consumption
时间窗: Baseline
Bruce treadmill protocol was used in the maximal exercise testing, maximum rate of oxygen consumption record as ml/kg/min
index of muscle stiffness
时间窗: Change from Baseline muscle quality at 3 months
elastography was used, units on kPa
次要结局
- physical activity level(Change from Baseline functional performance at 3 months)
- blood cholesterol(Change from Baseline functional performance at 3 months)
- characteristics of specific FTO genes(Baseline)
- blood glucose level(Change from Baseline functional performance at 3 months)
- BMI(Change from Baseline functional performance at 3 months)