Effect of Genetic Polymorphisms on Response to Beta Blocker Therapy in Egyptian Patients

Completed

• Conditions: Hypertension; Acute Coronary Syndrome

• Registration Number: NCT04900545
• Lead Sponsor: Mohamed Saleh Fayed

Brief Summary

Beta-blockers represent a cornerstone for the treatment of coronary artery disease (CAD). Their protective effect is based on the negative inotropic and chronotropic features, which have been tested in a large number of randomized controlled trials, both in patients with myocardial infarction (MI) and in those with stable angina, demonstrating a reduction of adverse cardiovascular events, a relief of symptoms and a reduction of myocardial ischemia

However, considerable interpatient variability in response to β-blockers has been reported which indicates that a considerable proportion of β-blocker-treated patients do not achieve the warranted cardio protection with β- blockers. This highlights the importance of identifying biomarkers associated with variability in response to β-blockers to improve the current approach for β- blocker selection, which seems to be suboptimal.

This study aims to study the effect of polymorphism in adrenergic beta receptors on beta-blocker response in Egyptian patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-05
• Study First Submitted: 2021-05-20
• Study First Submitted QC: 2021-05-21
• Primary Completion: 2021-05-25
• Study First Posted: 2021-05-25
• Study Completion: 2021-08-01
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-30
• Last Update Posted: 2022-12-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Beta-blockers naïve patients
2. Patients been on beta-blocker therapy for at least 4 weeks.
3. Age (18-75) Years old.

Exclusion Criteria

1. Non-Egyptians.
2. Kidney failure of any stage.
3. Liver failure of any stage.
4. Malignancy.
5. Pregnancy.
6. HR < 55 beats/min (in the absence of b-blocker therapy).
7. Presence of a cardiac pacemaker.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Adrenergic receptors genes and heart rate response to beta-blocker	Three months	Investigate the association of the adrenergic receptor polymorphisms with reduction in heart rate (expressed as beats per minute "BPM" ) in the Egyptian patients with acute coronary syndrome on beta blocker therapy.
Adrenergic receptors genes and blood pressure response to beta-blocker	Three months	Investigate the association of the adrenergic receptor polymorphisms with reduction in blood pressure (expressed in units of millimeters of mercury "mmHg" ) in the Egyptian patients with acute coronary syndrome on beta blocker therapy.

Trial Locations

Locations (1)

Ain Shams University Hospitals.; 🇪🇬 Cairo, Al Qahirah, Egypt