Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Progression of Coronary Plaque on Computed Tomography
研究概览
简要总结
This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults. The study will enroll approximately 10,000 participants aged 45 years or younger who undergo coronary CT scans at multiple hospitals across China.
Information collected at enrollment includes basic health information, cardiovascular risk factors, blood test results, medication use, lifestyle habits, and, for some participants, genetic data. Participants will undergo follow-up coronary CT scans after several years to evaluate changes in coronary artery plaque and disease progression.
By analyzing these clinical and imaging data, the study aims to identify factors associated with disease progression and to develop prediction models that may help estimate an individual's future risk of coronary plaque progression and cardiovascular events. The results of this study may contribute to improved risk assessment and early prevention strategies for coronary artery disease in young populations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 45 years at the time of enrollment.
- •Presence of symptoms suggestive of coronary artery disease and completion of coronary computed tomography (CT) examination.
- •Ability and willingness to provide written informed consent and to participate in follow-up assessments.
排除标准
- •Inability or unwillingness to complete follow-up assessments.
- •Inability to provide written informed consent.
- •History of coronary revascularization, including percutaneous coronary intervention or coronary artery bypass grafting.
- •Poor-quality coronary computed tomography images that are inadequate for reliable plaque assessment.
- •Presence of severe systemic disease with limited life expectancy that may interfere with study follow-up.
- •Pregnant or breastfeeding women.
- •Participation in another clinical study that may interfere with the outcomes of this study.
结局指标
主要结局
Progression of Coronary Plaque on Computed Tomography
时间窗: From baseline to follow-up coronary CT, up to 3 years
Progression of coronary atherosclerotic plaque assessed by comparing baseline and follow-up coronary computed tomography scans.
次要结局
未报告次要终点
研究者
Zhihui Hou
Associate Director, Department of Radiology
Fu Wai Hospital, Beijing, China