Carotid artery compression in preventing postoperative cognitive dysfunction in patients undergoing mitral valve replacement surgery: A randomized clinical trial
- Conditions
- Circulatory SystemMental and Behavioural Disorders
- Registration Number
- PACTR202401599878859
- Lead Sponsor
- Cairo University Hospitals
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 120
Patients scheduled for mitral valve replacement surgery
Patients aged 18-60 years
Disturbed Conscious Level (Glasgow Coma Scale less than 15)
Substance abuse
MMSE score less than 24 points
Emergency cases
Patients unable to read and write
Previous strokes or transient ischemic attacks
Significant carotid artery stenosis more than 50 %
Previous serious psychiatric or neurologic disorders
Previous atrial fibrillation within the last 6 months
Renal impairment, liver disease, or severe chronic obstructive pulmonary disease
A drop in mean arterial blood pressure by more than 20% before bypass and a mean arterial blood pressure less than 60 mmHg during bypass
End tidal CO2 less than 35 mmHg or more than 40 mmHg
Partial pressure of oxygen less than 150 mmHg or more than 250 mmHg
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method