Oral Curcumin Supplementation in Middle-Aged and Older Adults Improves Vascular Function

Not Applicable

• Conditions: Vascular Aging
• Interventions: Drug: High-dose curcumin pill; Drug: Low-dose curcumin pill; Drug: Placebo pill

• Registration Number: NCT01968564
• Lead Sponsor: University of Colorado, Boulder

Brief Summary

The proposed study will assess the ability of curcumin, the active ingredient in the Indian spice tumeric, to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2013-10-19
• Study First Submitted QC: 2013-10-19
• Study First Posted: 2013-10-24
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-17
• Last Update Posted: 2017-03-20
• Primary Completion: 2017-06
• Study Completion: 2017-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

• women must be postmenopausal
• body mass index (BMI) <40 kg/m2
• weight stable in the prior 3 months
• absence of clinical disease as determined by medical history, physical examination, blood and urine chemistries, ankle-brachial index, and a graded exercise stress test with monitoring of blood pressure and 12-lead ECG

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-dose curcumin pill	High-dose curcumin pill	-
Low-dose curcumin pill	Low-dose curcumin pill	-
Placebo pill	Placebo pill	-

Primary Outcome Measures

Name	Time	Method
Nitric-oxide mediated endothelium-dependent dilation	12 weeks	flow-mediated dilation and forearm blood flow responses to acetylcholine in the presence and absence of N'-monomethyl-L-arginine
Arterial Stiffness	12 weeks	Arterial pulse wave velocity

Secondary Outcome Measures

Name	Time	Method
Endothelial cell oxidative stress and inflammation	12 weeks	inflammatory and oxidative stress markers in biopsied vascular and arterial endothelial cells
Systemic oxidative stress and inflammation	12 weeks	circulating markers of oxidative stress and inflammation

Trial Locations

Locations (1)

University of Colorado Boulder, Clinical Translational Research Center; 🇺🇸 Boulder, Colorado, United States