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临床试验/NCT01956227
NCT01956227
已完成
1 期

Fall Risk Reduction in Multiple Sclerosis: Exercise Versus Behavior

University of Illinois at Urbana-Champaign1 个研究点 分布在 1 个国家目标入组 37 人2013年4月

概览

阶段
1 期
干预措施
未指定
疾病 / 适应症
Multiple Sclerosis
发起方
University of Illinois at Urbana-Champaign
入组人数
37
试验地点
1
主要终点
Fall incidence
状态
已完成
最后更新
11年前

概览

简要总结

Falls are a serious health concern for persons with multiple sclerosis (MS). Over 50% of persons with MS suffer a fall over a 6-month periodwith the majority of falls resulting in medical attention for injuries (i.e., lacerations, bone fractures, & head injuries). The effects of a fall are often compounded as it can lead to activity curtailment, physiological deconditioning, and institutionalization. Despite the importance of falls in persons with MS, the appropriate prevention strategies (i.e. rehabilitation approaches) are not clear. The purpose of this investigation is to determine whether exercise based or educational based interventions are more suited for fall prevention in older adults with MS.

详细描述

Falls are a serious health concern for persons with multiple sclerosis (MS). Over 50% of persons with MS suffer a fall over a 6-month periodwith the majority of falls resulting in medical attention for injuries (i.e., lacerations, bone fractures, \& head injuries). The effects of a fall are often compounded as it can lead to activity curtailment, physiological deconditioning, and institutionalization. Despite the importance of falls in persons with MS, the appropriate prevention strategies (i.e. rehabilitation approaches) are not clear. It is well known that causes of falls are multifactorial with over 400 risk factors identified. However, it is believed that these factors can be divided into two main classes: intrinsic (e.g. physiological factors) and extrinsic factors. For instance balance dysfunction, spasticity and muscle weakness are physiological risk factors for falls in MS . Behavioral fall risk factors in MS include choosing appropriate footwear, lighting and utilizing appropriate assistive device. There is evidence that both types of risk factors can be minimized with appropriately designed interventions in persons with MS and have been shown to reduce fall risk and incidence in other clinical populations. This has led to calls for the combination of exercise training program that targets specific, modifiable physiological risk factors and educational interventions targeting modifiable behavioral risk factors in persons with MS. However, there is minimal evidence that these interventions in isolation or combination actually reduce fall incidence or risk in persons with MS. This proposal seeks to determine the effectiveness of a combined exercise and educational rehabilitation strategy to prevent falls in persons with MS.

注册库
clinicaltrials.gov
开始日期
2013年4月
结束日期
2014年9月
最后更新
11年前
研究类型
Interventional
研究设计
Parallel
性别
All

研究者

入排标准

入选标准

  • Definite multiple sclerosis diagnosis
  • ambulatory
  • aged 50-75 years of age
  • fallen within 12 months

排除标准

  • non-ambulatory
  • outside age range
  • no fall history

结局指标

主要结局

Fall incidence

时间窗: 3 months

次要结局

  • Mobility(3 months)
  • Balance(3 Months)
  • Physiological Fall Risk(3 Months)

研究点 (1)

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