A Biobehavioral Approach to Understand the Multilevel Determinants of Cardiovascular Health in Black Women
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Blood Flow Measurements (Cerebral Blood Vessels)
研究概览
简要总结
This pilot study uses a state-of-the-science combination of remote behavioral monitoring, real-time experience sampling, in-lab physiological assessments, and extraction of neighborhood-level characteristics to (1) Examine the impact of daily experience (i.e., racial discrimination, affective states, stress) on health behaviors (i.e., physical activity, sedentary behavior, sleep) at the intrapersonal level among Black women; (2) Test the association between daily behaviors and impairments in biomarkers associated with vascular function/health (i.e., augmented systemic inflammation and oxidative stress, impaired peripheral/cerebral vascular function, increased large artery stiffness), as well as the impact of daily experience on the relationship between behaviors and vascular function; and (3) Explore the influence of neighborhood-level characteristics (i.e., social environment factors: i.e., neighborhood income and poverty, racial composition; and built environment context, such as park density and walkability) on daily experience and health behaviors.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •born and identified as female;
- •between 18-49 years old;
- •self-identify as Black or African American;
- •not currently pregnant;
- •ownership of a smartphone with Internet access;
- •able to speak and read English
排除标准
- •diagnosed hypertension, cardiovascular, respiratory, metabolic, and/or neurological disorders;
- •functional limitations or health issues that preclude physical activity;
- •currently taking medications for thyroid function or psychological conditions such as depression, anxiety, and mood disorders;
- •current use of oral or inhalant corticosteroids for asthma;
- •have regularly smoked within the last 2 years.
研究组 & 干预措施
Observational Group
Black women enrolled in this study will complete a series of lab-based assessments that evaluate their vascular health, followed by a 10-day free-living monitoring period with mobile and wearable devices.
干预措施: Observational Group (Behavioral)
结局指标
主要结局
Blood Flow Measurements (Cerebral Blood Vessels)
时间窗: Day 1
Cerebral blood flow will be indexed from the velocity of blood flowing through the middle cerebral artery. This will be accomplished using transcranial Doppler ultrasound.
Blood Flow Measurements (Large Blood Vessels)
时间窗: Day 1
A Doppler ultrasound probe will be used to measure blood flow in the upper arm, leg, and/or neck (e.g., brachial artery, femoral artery, and carotid artery, respectively).
Macrovascular function
时间窗: Day 1
Macrovascular function will be assessed as brachial artery vasodilation following a period of suprasystolic cuff occlusion. Microvascular function will be assessed as the % change in blood velocity from baseline following cuff release.
Arterial Stiffness
时间窗: Day 1
An appropriately sized blood pressure cuff will be placed on the upper arm and central (aortic) and peripheral (arm) blood pressure will be assessed using the non-invasive SphygmoCor Xcel device. This device provides measurement of augmentation index (in percentage), which is an indicator of arterial stiffness.
次要结局
- Physical activity(Day 2 to Day 11)
研究者
Yue Liao
Assistant Professor
The University of Texas at Arlington