跳至主要内容
临床试验/NCT05930171
NCT05930171已完成4 期

Analgesic Efficacy of Combined Lumbar Erector Spinae Plane Block and Pericapsular Nerve Group Block in Patients Undergoing Hip Surgeries

Menoufia University1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2023年2月1日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
4 期
状态
已完成
入组人数
24
试验地点
1
主要终点
Postoperative pain intensity

研究概览

简要总结

The investigators are going to evaluate the postoperative analgesic efficacy of combined LESPB and PENG block after hip surgeries.

详细描述

Hip surgeries are very common surgeries and has high postoperative pain potential. There are different ways to execute postoperative analgesia and each of them has advantages and disadvantages. As the patients submitted to this procedure are usually older and with multiple comorbidities, analgesia options with better profile of adverse effects should be preferred. Peripheral nerve block with long-acting local anesthetics is very suitable in this situation, in comparison with systemic or neuraxial opioids.

Pain control after total hip arthroplasty (THA) can be challenging because of complex innervation of the hip joint from both the lumbar and sacral nerve plexus. pain was the cause of 12% of unplanned hospital patient admissions, 60% of these patients were admitted for orthopedic concerns. The consequences of severe postoperative pain are prolonged hospital stay, increase hospital readmission, precipitation in the use of opioids with subsequent increase in postoperative nausea and vomiting, and overall low patient satisfaction. Furthermore, postoperative pain can seriously impact the physical and mental health of the patient and lead to secondary complications such as nausea, vomiting, slowed bowel movements, muscle spasms, thrombosis, cardiopulmonary complications and delayed recovery of organ functions.

The hip joint is innervated by the articular branches of multiple nerves that emerge from the lumbosacral plexus (L2-S1). The nerve supply to a specific region of the joint typically corresponds to the innervation of the muscle that crosses it :-

  • The femoral nerve innervates the anterior aspect
  • The obturator nerve supplies the inferior aspect
  • The superior gluteal nerve supplies the superior aspect
  • The nerve to the quadratus femoris innervates the posterior aspect.

Hip joint capsular innervation was found to consistently involve the femoral and obturator nerves, which supply the anterior capsule, and the nerve to the quadratus femoris, which supplies the posterior capsule.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged 18-70 years old
  • American Society of Anesthesiologists (ASA) class I to III
  • Scheduled for hip surgery.

排除标准

  • Refusal to participate
  • Allergy to any of the study drugs
  • Bleeding disorder
  • Localized infection
  • Neurological disease
  • Renal impairment
  • Psychological disorders
  • Opioid dependent
  • Intellectual disability (patients unable to express pain with visual analogue)
  • Morbid obesity.

研究组 & 干预措施

Group A: L-ESPB and PENG

Active Comparator

receiving after end of hip surgery (PENG) block first and (LESPB) at lumber 4 vertebrae level

干预措施: Ultrasound guided L-ESPB and PENG block using Bupivacaine (Procedure)

Group B: conventional analgesia

Active Comparator

receiving postoperative conventional analgesia in form of acetaminophen 15 mg/kg/6hrs

干预措施: Postoperative conventional analgesia in form of Acetaminophen (Drug)

结局指标

主要结局

Postoperative pain intensity

时间窗: at 24 hour after the block

Postoperative pain intensity using Visual Analogue Scale (VAS) (which is over 10 centimeter scale) (where 0 indicates no pain at all , 10 indicates severe pain)

次要结局

  • Vital signs(assessed at preoperative, postoperative (0,3,6,12,24 hours), Value is averaged of total measurements)
  • Time to first analgesic administration(24 hours postoperative)
  • Patient satisfaction(24 hours after the block)
  • Total Analgesic Requirements(24 hours postoperative)
  • Block failure (patients still feeling pain immediately after 1 hour from block)(1 hour after the block)
  • Adverse events(24 hours after the block)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ibrahim Walash

Assistant Lecturer of anesthesia, intensive care and pain management

Menoufia University

研究点 (1)

Loading locations...

相似试验

Combined Lumbar Erector Spinae Plane Block and... | 临床试验