Is the GLP-1 response to an oral glucose load increased in South Asians as compared to Western-Europeans?

Recruiting

Conditions: gut peptide GLP-1
sugar disease
10018424

Registration Number: NL-OMON40806

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

- 10 Male healthy volunteers of South Asian descent and 10 male healthy volunteers of western- european descent, born in the Netherlands
- Age > 18 years and * 25 years
- BMI > 20 kg/m2 and < 25 kg/m2

Exclusion Criteria

- A first degree (parent or sibling) relative with T2D
- Diabetes mellitus as defined by ADA criteria{2014 12 /id}
- Any significant chronic disease
- Renal, hepatic or endocrine disease
- Clinical cardiovascular disease, including complaints of angina pectoris or intermittend claudicatio
- Smoking
- Use of medication known to influence glucose and/or lipid metabolism
- Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
- Difficulties to insert an intravenous catheter
- Recent blood donation (within the last 3 months)
- Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- AUC GLP-1 in SA versus WE<br /><br>- peak GLP-1 level in SA versus WE<br /><br>- time to peak GLP-1 in SA versus WE<br /><br>- iinsulin sensitivity by Matsuda-index in SA versus WE</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- does peak GLP-1 in plasma precede the peak of plasma insulin?<br /><br>- insulin sensitivity by Matsuda-index in SA versus WE<br /><br>- is metabolic flexibility in SA impaired (switch from glucose to lipid<br /><br>metabolism and vice versa)</p><br>